4-Thiazoleacetic acid, a-(2-methyl-2-propenyl)-2-phenyl-

Base Information

• Chemical Name: 4-Thiazoleacetic acid, a-(2-methyl-2-propenyl)-2-phenyl-
• CAS No.: 597584-50-4
• Molecular Formula: C15H15NO2S
• Molecular Weight: 273.356
• Mol file: 597584-50-4.mol

Synonyms:

Chemical Property of 4-Thiazoleacetic acid, a-(2-methyl-2-propenyl)-2-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Thiazoleacetic acid, a-(2-methyl-2-propenyl)-2-phenyl-

There total 1 articles about 4-Thiazoleacetic acid, a-(2-methyl-2-propenyl)-2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

2-methyl-3-bromo-1-propene (1458-98-6) + (2-phenyl-1,3-thiazol-4-yl)acetic acid (16441-28-4) → 4-methyl-2-(2-phenyl-1,3-thiazol-4-yl)pent-4-enoic acid (597584-50-4)

Guidance literature:

(2-phenyl-1,3-thiazol-4-yl)acetic acid; With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 1h;

2-methyl-3-bromo-1-propene; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1021/jm0301078

Reference yield:

4-methyl-2-(2-phenyl-1,3-thiazol-4-yl)pent-4-enoic acid (597584-50-4) → 4-methyl-2-(2-phenyl-1,3-thiazol-4-yl)pentanoic acid (349671-18-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 8h; under 2068.59 Torr;

DOI:10.1021/jm0301078

Reference yield:

4-methyl-2-(2-phenyl-1,3-thiazol-4-yl)pent-4-enoic acid (597584-50-4) → N-cyanomethyl-4-methyl-2-(2-phenylthiazol-4-yl)pentanamide

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethanol / 8 h / 2068.59 Torr

2: 72 percent / PyBOP; TEA / dimethylformamide / 20 °C

With TEA; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm0301078

upstream raw materials:

2-methyl-3-bromo-1-propene

(2-phenyl-1,3-thiazol-4-yl)acetic acid

Downstream raw materials:

4-methyl-2-(2-phenyl-1,3-thiazol-4-yl)pentanoic acid

Refernces