2,5-Dihydroxy-3-Methoxybenzoic acid

Base Information

• Chemical Name: 2,5-Dihydroxy-3-Methoxybenzoic acid
• CAS No.: 5981-38-4
• Molecular Formula: C8H8O5
• Molecular Weight: 184.14600
• Mol file: 5981-38-4.mol

Synonyms:2,5-dihydroxy-3-methoxybenzoic acid;2,5-Dihydroxy-3-methoxy-benzoesaeure;2,5-Dihydroxy-3-methoxy-benzoic acid;

Chemical Property of 2,5-Dihydroxy-3-Methoxybenzoic acid

Chemical Property:

• PSA: 86.99000
• LogP: 0.80460

Purity/Quality:

95% ^*data from raw suppliers

2,5-Dihydroxy-3-methoxybenzoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-Dihydroxy-3-Methoxybenzoic acid

There total 3 articles about 2,5-Dihydroxy-3-Methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

3-methoxysalicylic acid (877-22-5) → 2,5-dihydroxy-3-methoxybenzoic acid (5981-38-4)

Guidance literature:

With sodium hydroxide; ammonium peroxydisulfate; In water; at 20 ℃; Cooling;

Reference yield:

2-methoxy-6-trifluoromethyl-hydroquinone (344-28-5) → 2,5-dihydroxy-3-methoxybenzoic acid (5981-38-4)

Guidance literature:

With sodium hydroxide;

Reference yield:

3-methoxy-5-(trifluoromethyl)phenol (349-56-4) → 2,5-dihydroxy-3-methoxybenzoic acid (5981-38-4)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂S₂O₈; aqueous NaOH

2: aqueous NaOH

With sodium hydroxide; dipotassium peroxodisulfate;

upstream raw materials:

3-methoxysalicylic acid

2-methoxy-6-trifluoromethyl-hydroquinone

3-methoxy-5-(trifluoromethyl)phenol

Downstream raw materials:

6-Methoxy-1,4-benzochinon-2-carbonsaeure-methylester

5-benzyloxy-2,3-dimethoxy-benzoic acid methyl ester

5-hydroxy-2,3-dimethoxy-benzoic acid

5-benzyloxy-2-hydroxy-3-methoxy-benzoic acid methyl ester

Refernces

• 1、 Kiep, Lutz,Burkhardt, Jens,Seifert, Karlheinz. "Drug metabolism studies with the incubated hen's egg: Identification of 2,3,5-trihydroxybenzoic acid as a metabolite of gentisic acid". experimental part. p. 469 - 474. Retrieved 2009/04/05.