Medazomide

Base Information

• Chemical Name: Medazomide
• CAS No.: 300-22-1
• Molecular Formula: C6H9N3O2
• Molecular Weight: 155.156
• Hs Code.: 2933990090
• European Community (EC) Number: 853-406-2
• UNII: 4Q1Q4V31K8
• DSSTox Substance ID: DTXSID5057705
• Nikkaji Number: J10.594E
• Wikidata: Q27260349
• NCI Thesaurus Code: C73182
• ChEMBL ID: CHEMBL2104736
• Mol file: 300-22-1.mol

Synonyms:medazomide;medazonamide

Chemical Property of Medazomide

Chemical Property:

• Vapor Pressure: 0.00185mmHg at 25°C
• Melting Point: 170-172 °C
• Refractive Index: 1.634
• Boiling Point: 292.3 °C at 760 mmHg
• PKA: 12.16±0.20(Predicted)
• Flash Point: 130.6 °C
• PSA: 75.76000
• Density: 1.45 g/cm³
• LogP: -0.84630
• XLogP3: -1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 155.069476538
• Heavy Atom Count: 11
• Complexity: 234

Purity/Quality:

99% ^*data from raw suppliers

1-methyl-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C(=O)CCC(=N1)C(=O)N

Technology Process of Medazomide

There total 4 articles about Medazomide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 1-methyl-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylate (90110-44-4) → 1-methyl-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxamide (300-22-1)

Guidance literature:

With ammonia; water;

Reference yield:

6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid (27372-38-9) → 1-methyl-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxamide (300-22-1)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl

2: methanol; sodium methylate

3: water; NH₃

With hydrogenchloride; methanol; ammonia; water; sodium methylate;

Reference yield:

methyl 6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylate (89532-94-5) → 1-methyl-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxamide (300-22-1)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; sodium methylate

2: water; NH₃

With methanol; ammonia; water; sodium methylate;

upstream raw materials:

methyl 1-methyl-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylate

6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid

methyl 6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylate