3-Oxazolidinecarboxylic acid, 2-[(1R)-1-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-oxo-7-(phenylmethoxy) heptyl]-4-phenyl-, 1,1-dimethylethyl ester, (2R,4R)-

Base Information

Chemical Name:3-Oxazolidinecarboxylic acid, 2-[(1R)-1-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-oxo-7-(phenylmethoxy) heptyl]-4-phenyl-, 1,1-dimethylethyl ester, (2R,4R)-
CAS No.:600143-35-9
Molecular Formula:C44H55NO6Si
Molecular Weight:722.009
Hs Code.:

3-Oxazolidinecarboxylic acid,
2-[(1R)-1-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-oxo-7-(phenylmethoxy)
heptyl]-4-phenyl-, 1,1-dimethylethyl ester, (2R,4R)-

Synonyms:

Suppliers and Price of 3-Oxazolidinecarboxylic acid, 2-[(1R)-1-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-oxo-7-(phenylmethoxy) heptyl]-4-phenyl-, 1,1-dimethylethyl ester, (2R,4R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Oxazolidinecarboxylic acid, 2-[(1R)-1-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-oxo-7-(phenylmethoxy) heptyl]-4-phenyl-, 1,1-dimethylethyl ester, (2R,4R)-

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Technology Process of 3-Oxazolidinecarboxylic acid, 2-[(1R)-1-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-oxo-7-(phenylmethoxy) heptyl]-4-phenyl-, 1,1-dimethylethyl ester, (2R,4R)-

There total 4 articles about 3-Oxazolidinecarboxylic acid, 2-[(1R)-1-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-oxo-7-(phenylmethoxy) heptyl]-4-phenyl-, 1,1-dimethylethyl ester, (2R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 600143-34-8
[2R,4R,2(1R,4RS)]-2-(7-benzyloxy-1-tert-butyldiphenylsilyloxy-4-hydroxyheptyl)-3-tert-butoxycarbonyl-4-phenyl-1,3-oxazolidine

: 600143-35-9
[2R,4R,2(1R)]-2-(7-benzyloxy-1-tert-butyldiphenylsilyloxy-4-oxoheptyl)-3-tert-butoxycarbonyl-4-phenyl-1,3-oxazolidine

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -50 ℃; for 0.666667h;
DOI:10.1002/ejoc.200300057

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 600143-35-9
[2R,4R,2(1R)]-2-(7-benzyloxy-1-tert-butyldiphenylsilyloxy-4-oxoheptyl)-3-tert-butoxycarbonyl-4-phenyl-1,3-oxazolidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 92 percent / sodium hydride / tetrahydrofuran / 12 h / 55 - 60 °C

2.1: 91 percent / osmium tetroxide; sodium periodate / H₂O; tetrahydrofuran / 4 h / 20 °C

3.1: Mg / diethyl ether

3.2: 98 percent / diethyl ether / 1 h / 0 °C

4.1: 94 percent / DMSO; oxalyl chloride / CH₂Cl₂ / 0.67 h / -50 °C

With sodium periodate; osmium(VIII) oxide; oxalyl dichloride; sodium hydride; magnesium; dimethyl sulfoxide; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1002/ejoc.200300057

Reference yield:

: 600143-33-7
[2R,4R,2(1R)]-3-tert-butoxycarbonyl-2-(1-tert-butyldiphenylsilyloxy-4-oxobutyl)-4-phenyl-1,3-oxazolidine

: 600143-35-9
[2R,4R,2(1R)]-2-(7-benzyloxy-1-tert-butyldiphenylsilyloxy-4-oxoheptyl)-3-tert-butoxycarbonyl-4-phenyl-1,3-oxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: Mg / diethyl ether

1.2: 98 percent / diethyl ether / 1 h / 0 °C

2.1: 94 percent / DMSO; oxalyl chloride / CH₂Cl₂ / 0.67 h / -50 °C

With oxalyl dichloride; magnesium; dimethyl sulfoxide; In diethyl ether; dichloromethane;
DOI:10.1002/ejoc.200300057