3-Oxazolidinecarboxylic acid, 2-[(1R)-1-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-7-(phenylmeth oxy)heptyl]-4-phenyl-, 1,1-dimethylethyl ester, (2R,4R)-

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Chemical Name:3-Oxazolidinecarboxylic acid, 2-[(1R)-1-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-7-(phenylmeth oxy)heptyl]-4-phenyl-, 1,1-dimethylethyl ester, (2R,4R)-
CAS No.:600143-34-8
Molecular Formula:C44H57NO6Si
Molecular Weight:724.025
Hs Code.:

3-Oxazolidinecarboxylic acid,
2-[(1R)-1-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-7-(phenylmeth
oxy)heptyl]-4-phenyl-, 1,1-dimethylethyl ester, (2R,4R)-

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Chemical Property of 3-Oxazolidinecarboxylic acid, 2-[(1R)-1-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-7-(phenylmeth oxy)heptyl]-4-phenyl-, 1,1-dimethylethyl ester, (2R,4R)-

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Technology Process of 3-Oxazolidinecarboxylic acid, 2-[(1R)-1-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-7-(phenylmeth oxy)heptyl]-4-phenyl-, 1,1-dimethylethyl ester, (2R,4R)-

There total 3 articles about 3-Oxazolidinecarboxylic acid, 2-[(1R)-1-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-7-(phenylmeth oxy)heptyl]-4-phenyl-, 1,1-dimethylethyl ester, (2R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 54314-84-0
1-[(3-bromopropoxy)methyl]-benzene

: 600143-33-7
[2R,4R,2(1R)]-3-tert-butoxycarbonyl-2-(1-tert-butyldiphenylsilyloxy-4-oxobutyl)-4-phenyl-1,3-oxazolidine

: 600143-34-8
[2R,4R,2(1R,4RS)]-2-(7-benzyloxy-1-tert-butyldiphenylsilyloxy-4-hydroxyheptyl)-3-tert-butoxycarbonyl-4-phenyl-1,3-oxazolidine

Guidance literature:: 1-[(3-bromopropoxy)methyl]-benzene; With magnesium; In diethyl ether;

[2R,4R,2(1R)]-3-tert-butoxycarbonyl-2-(1-tert-butyldiphenylsilyloxy-4-oxobutyl)-4-phenyl-1,3-oxazolidine; In diethyl ether; at 0 ℃; for 1h;
DOI:10.1002/ejoc.200300057

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 600143-34-8
[2R,4R,2(1R,4RS)]-2-(7-benzyloxy-1-tert-butyldiphenylsilyloxy-4-hydroxyheptyl)-3-tert-butoxycarbonyl-4-phenyl-1,3-oxazolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 92 percent / sodium hydride / tetrahydrofuran / 12 h / 55 - 60 °C

2.1: 91 percent / osmium tetroxide; sodium periodate / H₂O; tetrahydrofuran / 4 h / 20 °C

3.1: Mg / diethyl ether

3.2: 98 percent / diethyl ether / 1 h / 0 °C

With sodium periodate; osmium(VIII) oxide; sodium hydride; magnesium; In tetrahydrofuran; diethyl ether; water;
DOI:10.1002/ejoc.200300057

Reference yield:

: 600143-32-6
[2R,4R,2(1R)]-3-tert-butoxycarbonyl-2-(1-tert-butyldiphenylsilyloxypent-4-enyl)-4-phenyl-1,3-oxazolidine

: 600143-34-8
[2R,4R,2(1R,4RS)]-2-(7-benzyloxy-1-tert-butyldiphenylsilyloxy-4-hydroxyheptyl)-3-tert-butoxycarbonyl-4-phenyl-1,3-oxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 91 percent / osmium tetroxide; sodium periodate / H₂O; tetrahydrofuran / 4 h / 20 °C

2.1: Mg / diethyl ether

2.2: 98 percent / diethyl ether / 1 h / 0 °C

With sodium periodate; osmium(VIII) oxide; magnesium; In tetrahydrofuran; diethyl ether; water;
DOI:10.1002/ejoc.200300057