2-Chloro-1-(4-o-tolylpiperazin-1-yl)ethanone

Base Information

Chemical Name:2-Chloro-1-(4-o-tolylpiperazin-1-yl)ethanone
CAS No.:60121-79-1
Molecular Formula:C13H17ClN2O
Molecular Weight:252.744
Hs Code.:
DSSTox Substance ID:DTXSID10406296
Wikidata:Q82211205

Synonyms:60121-79-1;2-chloro-1-(4-o-tolylpiperazin-1-yl)ethanone;2-chloro-1-[4-(2-methylphenyl)piperazin-1-yl]ethanone;Piperazine, 1-(chloroacetyl)-4-(2-methylphenyl)-;SCHEMBL8691022;DTXSID10406296;KCVPIBOBZYTYNG-UHFFFAOYSA-N;AKOS003590697;2-Chloro-1-(4-(o-tolyl)piperazin-1-yl)ethanone;F1908-1860;2-chloro-1-[4-(2-methylphenyl)piperazin-1-yl]ethan-1-one

Suppliers and Price of 2-Chloro-1-(4-o-tolylpiperazin-1-yl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 2-Chloro-1-(4-o-tolylpiperazin-1-yl)ethanone

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:252.1029409
Heavy Atom Count:17
Complexity:264

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=CC=C1N2CCN(CC2)C(=O)CCl

Technology Process of 2-Chloro-1-(4-o-tolylpiperazin-1-yl)ethanone

There total 2 articles about 2-Chloro-1-(4-o-tolylpiperazin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 39512-51-1
1-(o-toluyl)piperazine

: 79-04-9
chloroacetyl chloride

: 60121-79-1
2-chloro-1-[4-(o-tolyl)-piperazin-1-yl]-acetamide

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 0 - 20 ℃; for 16h;
DOI:10.1021/acsmedchemlett.6b00186

Reference yield:

: 60121-79-1
2-chloro-1-[4-(o-tolyl)-piperazin-1-yl]-acetamide

Guidance literature:

Reference yield: 90.0%

: 19788-36-4
4-hydroxymethyl-3,5-dimethylisoxazole

: 60121-79-1
2-chloro-1-[4-(o-tolyl)-piperazin-1-yl]-acetamide

: 2-((3,5-dimethylisoxazol-4-yl)methoxy)-1-(4-(o-tolyl)piperazin-1-yl)ethan-1-one

Guidance literature:: 4-hydroxymethyl-3,5-dimethylisoxazole; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h;

2-chloro-1-[4-(o-tolyl)-piperazin-1-yl]-acetamide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 20h;
DOI:10.1021/acsmedchemlett.6b00186