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Itraconazolum [Latin]

Base Information Edit
  • Chemical Name:Itraconazolum [Latin]
  • CAS No.:84604-65-9
  • Molecular Formula:C35H38Cl2N8O4
  • Molecular Weight:705.644
  • Hs Code.:
  • European Community (EC) Number:617-596-9,831-526-6
  • Nikkaji Number:J23.733G
  • Wikipedia:Itraconazole
  • Wikidata:Q27166205
  • NCI Thesaurus Code:C1138
  • RXCUI:28031
  • Pharos Ligand ID:GH19ZLBQMZZL
  • ChEMBL ID:CHEMBL64391
  • Mol file:84604-65-9.mol
Itraconazolum [Latin]

Synonyms:Itraconazole;Orungal;R 51211;R-51211;R51211;Sporanox

Suppliers and Price of Itraconazolum [Latin]
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
Total 5 raw suppliers
Chemical Property of Itraconazolum [Latin] Edit
Chemical Property:
  • Boiling Point:850°Cat760mmHg 
  • Flash Point:467.9°C 
  • Density:1.4g/cm3 
  • XLogP3:5.7
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:9
  • Rotatable Bond Count:11
  • Exact Mass:704.2393071
  • Heavy Atom Count:49
  • Complexity:1120
Purity/Quality:

99% *data from raw suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Drug Classes:Antifungal Agents
  • Canonical SMILES:CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl
  • Recent ClinicalTrials:Comparison of Efficacy of Single Oral Dose Fluconazole and Itraconazole in Patients With Pityriasis Versicolor
  • Recent EU Clinical Trials:Signal TrAnsduction Pathway activity analysis for OVarian cancER treatment. STAPOVER study
  • Recent NIPH Clinical Trials:Clinical pharmacology study to evaluate the drug-drug interactions of TAS-115 in healthy subjects
Technology Process of Itraconazolum [Latin]

There total 6 articles about Itraconazolum [Latin] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
Multi-step reaction with 3 steps
1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 18 h / 20 - 110 °C / Inert atmosphere
2: hydrogen bromide; water / toluene / Reflux
3: caesium carbonate / dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere
With water; hydrogen bromide; caesium carbonate; In 1-methyl-pyrrolidin-2-one; dimethyl sulfoxide; toluene;
DOI:10.1021/acs.jmedchem.5b01718
Guidance literature:
Multi-step reaction with 2 steps
1: hydrogen bromide; water / toluene / Reflux
2: caesium carbonate / dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere
With water; hydrogen bromide; caesium carbonate; In dimethyl sulfoxide; toluene;
DOI:10.1021/acs.jmedchem.5b01718
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