3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl )-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-[ (1S)-1-methylpropyl]-

Base Information

Chemical Name:3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl )-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-[ (1S)-1-methylpropyl]-
CAS No.:154003-20-0
Molecular Formula:C35H38Cl2N8O4
Molecular Weight:705.644
Hs Code.:
Mol file:154003-20-0.mol

3H-1,2,4-Triazol-3-one,
4-[4-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl
)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-[
(1S)-1-methylpropyl]-

Synonyms:

Suppliers and Price of 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl )-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-[ (1S)-1-methylpropyl]-

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Chemical Property of 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl )-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-[ (1S)-1-methylpropyl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl )-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-[ (1S)-1-methylpropyl]-

There total 6 articles about 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl )-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-[ (1S)-1-methylpropyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 125235-31-6
(S)-2-(sec-butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

: 154003-21-1,113770-65-3
((2S,4S)-2-((1H-1,2,4-triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-methyl-benzenesulfonate

: 154003-20-0,252964-65-1,873066-43-4
(2S,4R,2'R)-Itraconazole

Guidance literature:: With sodium hydride; In dimethyl sulfoxide; at 50 - 85 ℃;
DOI:10.1021/ml1000068

Reference yield:

: 58905-16-1
1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

: 154003-20-0,252964-65-1,873066-43-4
(2S,4R,2'R)-Itraconazole

Guidance literature:: Multi-step reaction with 5 steps

1: trifluorormethanesulfonic acid / toluene / 6 h / 80 °C

2: N,N-dimethyl-formamide / 20 h / 130 °C

3: lithium hydroxide / ethanol / 6 h / 10 °C

4: triethylamine / dichloromethane / 10 h / -20 - 25 °C

5: sodium hydride / N,N-dimethyl-formamide / 25 h / 30 - 40 °C

With trifluorormethanesulfonic acid; sodium hydride; triethylamine; lithium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 84604-65-9,84625-61-6,252964-65-1,873066-43-4
itraconazole

: 154003-17-5,252964-65-1,873066-43-4
(2R,4S,2'S)-Itraconazole

: 154003-18-6,252964-65-1,873066-43-4
(2R,4S,2'R)-Itraconazole

: 154003-19-7,252964-65-1,873066-43-4
(2S,4R,2'S)-Itraconazole

: 154003-20-0,252964-65-1,873066-43-4
(2S,4R,2'R)-Itraconazole

Guidance literature:: With Chiralcel OD chiral stationary phase; In ethanol; hexane; isopropyl alcohol; acetonitrile; at 40 ℃; stereoselective reaction; Resolution of racemate;
DOI:10.1002/chir.20932