Welcome to LookChem.com Sign In|Join Free

CAS

  • or

5922-60-1

Post Buying Request

5922-60-1 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

5922-60-1 Usage

Chemical Properties

white to light beige crystalline needles

Uses

2-Amino-5-chlorobenzonitrile was used to build up the 2,2-dioxide-1H-2,1,3-benzothiadiazine ring system.

Preparation

Synthesis of 2-amino-5-chlorobenzonitrile is reported in the literature by two methods. The first method involves synthesis from 2-aminobenzonitrile, N-chlorosuccinimide an d acetonitrile. The second method involves synthesis from 5-chloroisatin-β-oxime and bis(2-ethylhexyl)phthalate. Both the methods are not feasible commercially as far as the cost and availability of raw materials are concerned.

General Description

The vibrational spectra of 2-amino-5-chlorobenzonitrile was studied using density functinal theory.

Check Digit Verification of cas no

The CAS Registry Mumber 5922-60-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,9,2 and 2 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 5922-60:
(6*5)+(5*9)+(4*2)+(3*2)+(2*6)+(1*0)=101
101 % 10 = 1
So 5922-60-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H5ClN2/c8-6-1-2-7(10)5(3-6)4-9/h1-3H,10H2

5922-60-1 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (B22690)  2-Amino-5-chlorobenzonitrile, 97%   

  • 5922-60-1

  • 1g

  • 463.0CNY

  • Detail
  • Alfa Aesar

  • (B22690)  2-Amino-5-chlorobenzonitrile, 97%   

  • 5922-60-1

  • 5g

  • 837.0CNY

  • Detail

5922-60-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Amino-5-chlorobenzonitrile

1.2 Other means of identification

Product number -
Other names Benzonitrile,2-amino-5-chloro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5922-60-1 SDS

5922-60-1Synthetic route

anthranilic acid nitrile
1885-29-6

anthranilic acid nitrile

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
With N-chloro-succinimide; isopropyl alcohol for 0.25h; Chlorination; Heating;89%
With N-chloro-succinimide In acetonitrile for 1.5h; Heating;71%
4-chloro-2-bromoaniline
873-38-1

4-chloro-2-bromoaniline

copper(l) cyanide

copper(l) cyanide

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
In 1-methyl-pyrrolidin-2-one at 140℃; for 5h;80%
5-chloro-2-(2,5-dimethyl-1H-pyrrol-1-yl)benzonitrile

5-chloro-2-(2,5-dimethyl-1H-pyrrol-1-yl)benzonitrile

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
With hydroxylamine hydrochloride In ethanol; water at 120℃; for 0.5h; Microwave irradiation;76%
2-Amino-5-chlorobenzamide
5202-85-7

2-Amino-5-chlorobenzamide

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
With phosphorus pentaoxide for 0.5h;63%
5-chloro-2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)benzonitrile
1192690-74-6

5-chloro-2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)benzonitrile

A

3-amino-5-chloroindole-2-carbonitrile
1192691-01-2

3-amino-5-chloroindole-2-carbonitrile

B

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
With water; triphenylphosphine In dichloromethane at 20℃;A 32%
B 27%
methylmagnesium bromide
75-16-1

methylmagnesium bromide

2-azido-5-chlorobenzonitrile
156149-36-9

2-azido-5-chlorobenzonitrile

A

6-chloro-3,4-dihydro-4-imino-3-methyl-1,2,3-benzotriazine
1262111-20-5

6-chloro-3,4-dihydro-4-imino-3-methyl-1,2,3-benzotriazine

B

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 1h;A 31%
B 29%
5-Chloroisatin 3-oxime
85124-16-9

5-Chloroisatin 3-oxime

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
at 250℃;
3-chloro-6-nitrobenzonitrile
34662-31-2

3-chloro-6-nitrobenzonitrile

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
With tin(ll) chloride Yield given;
With titanium(III) chloride In water; acetone for 0.5h;
With hydrogen In neat (no solvent) at 110℃; under 15001.5 Torr; for 15h; chemoselective reaction;
4-chloro-aniline
106-47-8

4-chloro-aniline

trichloroacetonitrile
545-06-2

trichloroacetonitrile

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
With boron trichloride; tin(IV) chloride; potassium carbonate 1.) C6H6, reflux, 6 h, 2.) CH3OH, reflux, 2.5 h,; Yield given. Multistep reaction;
p-chloro-o-iodoaniline
63069-48-7

p-chloro-o-iodoaniline

CuCN

CuCN

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
With pyridine
N-(4-Chloro-2-cyanophenyl)-2,2,2-trifluoroacetamide
618889-14-8

N-(4-Chloro-2-cyanophenyl)-2,2,2-trifluoroacetamide

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
With potassium carbonate In methanol at 20℃; for 12h;
p-chloro-o-iodoaniline
63069-48-7

p-chloro-o-iodoaniline

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dimethylformamide / 0.5 h / 20 °C
2: dimethylformamide / 0.5 h / 100 °C
3: aq. K2CO3 / methanol / 12 h / 20 °C
View Scheme
2,2,2-trifluoro-N-(2-iodo-4-chlorophenyl)acetamide
784183-51-3

2,2,2-trifluoro-N-(2-iodo-4-chlorophenyl)acetamide

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dimethylformamide / 0.5 h / 100 °C
2: aq. K2CO3 / methanol / 12 h / 20 °C
View Scheme
anthranilic acid
118-92-3

anthranilic acid

1-chloro-4-methyl-thioxanthone

1-chloro-4-methyl-thioxanthone

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 35 percent / sulfuryl chloride; hydrochloric acid / diethyl ether / 1.5 h / 60 - 70 °C
2: 37 percent / thionyl chloride / 0.5 h / Heating
3: 68 percent / liq. ammonia / 0.5 h / 0 °C
4: 63 percent / phosphorus pentoxide / 0.5 h
View Scheme
5-chloroanthranilic acid
635-21-2

5-chloroanthranilic acid

4-halogen-1-amino-anthraquinone

4-halogen-1-amino-anthraquinone

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 37 percent / thionyl chloride / 0.5 h / Heating
2: 68 percent / liq. ammonia / 0.5 h / 0 °C
3: 63 percent / phosphorus pentoxide / 0.5 h
View Scheme
2-amino-5-chlorobenzoic chloride
910230-30-7

2-amino-5-chlorobenzoic chloride

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 68 percent / liq. ammonia / 0.5 h / 0 °C
2: 63 percent / phosphorus pentoxide / 0.5 h
View Scheme
5-chloro-2-nitrobenzoic acid
2516-95-2

5-chloro-2-nitrobenzoic acid

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) SOCl2; 2.) NH4OH / 1.) PhMe, reflux
2: SOCl2 / Heating
3: 15 percent TiCl3 / acetone; H2O / 0.5 h
View Scheme
2-nitro-5-chlorobenzamide
40763-96-0

2-nitro-5-chlorobenzamide

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: SOCl2 / Heating
2: 15 percent TiCl3 / acetone; H2O / 0.5 h
View Scheme
5-chloro-2-nitrobenzaldehyde oxime
93033-30-8

5-chloro-2-nitrobenzaldehyde oxime

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / PCl5
2: SnCl2
View Scheme
n-Butyl chloride
109-69-3

n-Butyl chloride

anthranilic acid nitrile
1885-29-6

anthranilic acid nitrile

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Conditions
ConditionsYield
With N-chloro-succinimide In acetonitrile
carbon dioxide
124-38-9

carbon dioxide

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

6-chloro-1,2,3,4-tetrahydroquinazoline-2,4-dione
1640-60-4

6-chloro-1,2,3,4-tetrahydroquinazoline-2,4-dione

Conditions
ConditionsYield
With bicarbonate salt of 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 80℃; under 750.075 Torr; for 4h; Inert atmosphere;100%
With potassium carbonate; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride In dimethyl sulfoxide at 120℃; under 750.075 Torr; for 8h; High pressure; Autoclave;99%
With tetrabutyl ammonium fluoride In dimethyl sulfoxide at 110℃; under 15001.5 Torr; for 24h; Autoclave;99%
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

4-Methoxybenzyl alcohol
105-13-5

4-Methoxybenzyl alcohol

5-chloro-2-(4-methoxy-benzylamino)-benzonitrile
685540-87-8

5-chloro-2-(4-methoxy-benzylamino)-benzonitrile

Conditions
ConditionsYield
With toluene-4-sulfonic acid In acetonitrile at 70℃; for 12h;99%
chloro-formamidine hydrochloride

chloro-formamidine hydrochloride

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

2,4-diamino-6-chloroquinazoline
18671-95-9

2,4-diamino-6-chloroquinazoline

Conditions
ConditionsYield
Stage #1: chloro-formamidine hydrochloride; 2-amino-5-chlorobenzonitrile In sulfolane; dimethylsulfone at 165℃; for 0.5h;
Stage #2: With ammonia; water In sulfolane; dimethylsulfone pH=7 - 8;
99%
Stage #1: chloro-formamidine hydrochloride; 2-amino-5-chlorobenzonitrile In sulfolane; dimethylsulfone at 165℃; for 0.5h;
Stage #2: With ammonia; water In sulfolane; dimethylsulfone pH=7 - 8;
99%
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

2-azido-5-chlorobenzonitrile
156149-36-9

2-azido-5-chlorobenzonitrile

Conditions
ConditionsYield
With tert.-butylnitrite; trimethylsilylazide In acetonitrile at 20℃; for 2h;97%
Stage #1: 2-amino-5-chlorobenzonitrile With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 0.5h;
Stage #2: With sodium azide; sodium acetate In water at 0 - 5℃; for 0.5h;
72%
With hydrogenchloride; sodium azide; sodium acetate; sodium nitrite 1.) water, 0-5 deg C, 10 min; 2.) water, 0-5 deg C, 0.5 h; Multistep reaction;
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

methyl chloroformate
79-22-1

methyl chloroformate

5-chloro-2-<(methoxycarbonyl)amino>benzonitrile
104615-85-2

5-chloro-2-<(methoxycarbonyl)amino>benzonitrile

Conditions
ConditionsYield
With sodium hydrogencarbonate Reflux;97%
With sodium hydrogencarbonate In butanone Reflux;97%
With sodium hydrogencarbonate In butanone Reflux;97%
With sodium hydrogencarbonate In butanone at 80℃; for 18h;76%
With dmap In N,N-dimethyl acetamide at 10 - 90℃;
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

2-Amino-5-chlorobenzamide
5202-85-7

2-Amino-5-chlorobenzamide

Conditions
ConditionsYield
With silica-gel-supported sulfuric acid In toluene for 2.5h; Inert atmosphere; Reflux;97%
With water; potassium carbonate In water at 150℃; for 0.5h; Microwave irradiation;89%
With potassium hydroxide; ethanol Heating / reflux;
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Triethyl orthopropionate
115-80-0

Triethyl orthopropionate

ethyl N-(4-chloro-2-cyanophenyl)propanimidate
1088610-86-9

ethyl N-(4-chloro-2-cyanophenyl)propanimidate

Conditions
ConditionsYield
With trifluoroacetic acid97%
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

2-(aminomethyl)-4-chloroaniline
108047-39-8

2-(aminomethyl)-4-chloroaniline

Conditions
ConditionsYield
With borane-THF In tetrahydrofuran at 0 - 20℃; for 24.17h; Inert atmosphere;96%
With borane-THF In tetrahydrofuran at 0 - 20℃; for 24.1667h; Inert atmosphere;50%
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 18h;
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

phenylboronic acid
98-80-6

phenylboronic acid

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate; water In 2-methyltetrahydrofuran at 80℃; for 36h; Schlenk technique;96%
With [2,2]bipyridinyl; methanesulfonic acid; palladium(II) trifluoroacetate In tetrahydrofuran; water at 80℃; for 36h;
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

2-amino-5-chlorobenzothioamide
25465-36-5

2-amino-5-chlorobenzothioamide

Conditions
ConditionsYield
With sodium hydrogen sulfide monohydrate; magnesium chloride In N,N-dimethyl-formamide at 20℃; for 72h; Sealed tube;96%
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

d5-phenylboronic acid

d5-phenylboronic acid

C14H8(2)H4ClNO3

C14H8(2)H4ClNO3

Conditions
ConditionsYield
With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate In 2-methyltetrahydrofuran; water at 80℃; for 12h; Reagent/catalyst; Temperature; Sealed tube; Inert atmosphere; Cooling with ice;96%
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

6-chloro-1,2,3,4-tetrahydroquinazoline-2,4-dione
1640-60-4

6-chloro-1,2,3,4-tetrahydroquinazoline-2,4-dione

Conditions
ConditionsYield
With carbon dioxide In water at 150℃; under 37503.8 Torr; for 5h;95.6%
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

4-amino-6-chloroquinazoline
19808-35-6

4-amino-6-chloroquinazoline

Conditions
ConditionsYield
Stage #1: 2-amino-5-chlorobenzonitrile; formamide at 180℃; for 6h;
Stage #2: With water
95%
at 180℃; for 6h;95%
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

benzoyl chloride
98-88-4

benzoyl chloride

N-(4-chloro-2-cyanophenyl)benzonitrile
84197-47-7

N-(4-chloro-2-cyanophenyl)benzonitrile

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 3h;94%
carbon disulfide
75-15-0

carbon disulfide

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

6-chloroquinazoline-2,4(1H,3H)-dithione

6-chloroquinazoline-2,4(1H,3H)-dithione

Conditions
ConditionsYield
With C7H14OS2*C9H16N2 In neat (no solvent) at 40℃; for 18h; Green chemistry;94%
ortho-bromophenylacetic acid
18698-97-0

ortho-bromophenylacetic acid

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

2-(2-bromophenyl)-N-(4-chloro-2-cyanophenyl)acetamide

2-(2-bromophenyl)-N-(4-chloro-2-cyanophenyl)acetamide

Conditions
ConditionsYield
Stage #1: ortho-bromophenylacetic acid With thionyl chloride In dichloromethane for 4h; Reflux;
Stage #2: 2-amino-5-chlorobenzonitrile In toluene for 16h; Reflux;
94%
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

cycloheptanone
502-42-1

cycloheptanone

2-chloro-6H,7H,8H,9H,10H-cyclohepta[b]quinolin-11-amine hydrochloride

2-chloro-6H,7H,8H,9H,10H-cyclohepta[b]quinolin-11-amine hydrochloride

Conditions
ConditionsYield
Stage #1: 2-amino-5-chlorobenzonitrile; cycloheptanone With aluminum (III) chloride at 150℃; for 0.166667h; Microwave irradiation;
Stage #2: With hydrogenchloride In methanol; water at 20℃;
94%
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

(2-cyano-4-chloro-phenyl)-carbamic acid ethyl ester
104615-49-8

(2-cyano-4-chloro-phenyl)-carbamic acid ethyl ester

Conditions
ConditionsYield
for 6h; Reflux;93%
at 93℃; for 18h;85%
for 6h; Reflux;68%
for 6h; Heating;
Reflux;
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

Benzyldithiophosphonsaeureanhydrid
15239-25-5

Benzyldithiophosphonsaeureanhydrid

2-Benzyl-6-chloro-2-thioxo-1,2-dihydro-2λ5-benzo[d][1,3,2]thiazaphosphinin-4-ylideneamine

2-Benzyl-6-chloro-2-thioxo-1,2-dihydro-2λ5-benzo[d][1,3,2]thiazaphosphinin-4-ylideneamine

Conditions
ConditionsYield
In toluene at 90℃; for 3h;92%
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

A

(2-amino-5-chlorophenyl)-phenyl-methane-imine
5606-39-3

(2-amino-5-chlorophenyl)-phenyl-methane-imine

B

phenylmagnesium bromide
100-58-3

phenylmagnesium bromide

Conditions
ConditionsYield
A 92%
B n/a
1,1,1-trimethoxybutane
43083-12-1

1,1,1-trimethoxybutane

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

methyl N-(4-chloro-2-cyanophenyl)butanimidate
1088610-88-1

methyl N-(4-chloro-2-cyanophenyl)butanimidate

Conditions
ConditionsYield
With trifluoroacetic acid92%
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

2-amino-3-bromo-5-chlorobenzonitrile
914636-84-3

2-amino-3-bromo-5-chlorobenzonitrile

Conditions
ConditionsYield
With bromine; sodium bromide In water at 25℃; for 0.5h;92%
With bromine In acetic acid at 50℃;
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

sodium benzenesulfonate
873-55-2

sodium benzenesulfonate

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With p-nitrobenzenesulfonic acid; palladium diacetate In tetrahydrofuran; water at 80℃; for 48h; Inert atmosphere; Schlenk technique;92%
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

4-methylphenylboronic acid
5720-05-8

4-methylphenylboronic acid

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

6-chloro-2-methyl-4-(p-tolyl)quinazoline

6-chloro-2-methyl-4-(p-tolyl)quinazoline

Conditions
ConditionsYield
With [2,2]bipyridinyl; palladium diacetate; acetic acid In N,N-dimethyl-formamide at 100℃; for 12h;91%
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

5-<4-(trifluoromethyl)phenyl>-1,3-cyclohexanedione
55579-69-6

5-<4-(trifluoromethyl)phenyl>-1,3-cyclohexanedione

5-chloro-2-<<5-<4-(trifluoromethyl)phenyl>-3-oxo-1-cyclohexenyl>amino>benzonitrile
144155-89-5

5-chloro-2-<<5-<4-(trifluoromethyl)phenyl>-3-oxo-1-cyclohexenyl>amino>benzonitrile

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 8h; Heating;90.58%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

2,4,6-trichloroquinazoline
20028-68-6

2,4,6-trichloroquinazoline

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate With triethylamine; Triphenylphosphine oxide In chlorobenzene at 20℃; for 0.5h; Cooling with ice;
Stage #2: 2-amino-5-chlorobenzonitrile In chlorobenzene at 120℃; for 8h;
90.3%
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

(E)-N′-(4-chloro-2-cyanophenyl)-N,N-dimethylformimidamide

(E)-N′-(4-chloro-2-cyanophenyl)-N,N-dimethylformimidamide

Conditions
ConditionsYield
at 70 - 75℃; for 2h;90%
In methanol for 6h; Reflux;
N,4-dimethyl-N-(phenylethynyl)benzenesulfonamide
1005500-77-5

N,4-dimethyl-N-(phenylethynyl)benzenesulfonamide

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

N-(4-amino-6-chloro-3-phenylquinolin-2-yl)-N,4-dimethylbenzenesulfonamide

N-(4-amino-6-chloro-3-phenylquinolin-2-yl)-N,4-dimethylbenzenesulfonamide

Conditions
ConditionsYield
With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I) In 1,4-dioxane at 80℃; for 7h; Schlenk technique; regioselective reaction;90%
Ethyldithioxo-λ5-phosphoran
41391-49-5

Ethyldithioxo-λ5-phosphoran

2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

6-Chloro-2-ethyl-2-thioxo-1,2-dihydro-2λ5-benzo[d][1,3,2]thiazaphosphinin-4-ylideneamine

6-Chloro-2-ethyl-2-thioxo-1,2-dihydro-2λ5-benzo[d][1,3,2]thiazaphosphinin-4-ylideneamine

Conditions
ConditionsYield
In toluene at 90℃; for 3h;89%

5922-60-1Relevant articles and documents

A PROCESS FOR THE SYNTHESIS ANTHRANILIC DIAMIDE COMPOUNDS AND INTERMEDIATES THEREOF

-

Page/Page column 25; 26, (2020/09/08)

The present invention disclosed a process for the synthesis of anthranilic diamide compound of formula (I), wherein, R1, R2, R3a, R3b, R3c, R4, R5, R6 and Z are as defined in the detailed description. The process comprising the step of obtaining a mono- or dicyano substituted aniline compound of formula (IV) which is then converted to an anthranilic acid compound of formula (V) or an anthranilic amide compound of formula (Va). Further, the compound of formula (VI) can be optionally synthesized from compound of formula (IV or V or Va).

Microwave-assisted protection of primary amines as 2,5-dimethylpyrroles and their orthogonal deprotection

Walia, Amit,Kang, Soosung,Silverman, Richard B

, p. 10931 - 10937 (2013/11/19)

Primary amines can be readily doubly protected as N-substituted 2,5-dimethylpyrroles. Although this protecting group is stable toward strong bases and nucleophiles, long reaction times are required for both the protection and deprotection steps, generally resulting in low deprotection yields. By employing microwave irradiation, protection and deprotection reaction times are dramatically reduced. Furthermore, deprotection with dilute hydrochloric acid in ethanol increases reaction yields. Diverse deprotection conditions have been developed in conjunction with microwave irradiation, so that protection as an N-substituted 2,5-dimethylpyrrole can be orthogonal to other standard amine protecting groups, such as tert-butyloxycarbonyl (Boc), carbobenzyloxy (Cbz), and 9-fluorenylmethyloxycarbonyl (Fmoc).

The conversion of 2-(4-chloro-5H-1,2,3-dithiazolylideneamino)benzonitriles into 3-aminoindole-2-carbonitriles using triphenylphosphine

Michaelidou, Sophia S.,Koutentis, Panayiotis A.

experimental part, p. 8428 - 8433 (2009/12/26)

2-(4-Chloro-5H-1,2,3-dithiazolylideneamino)benzonitrile 1a reacts with triphenylphosphine (4 equiv) in the presence of water (2 equiv) to afford anthranilonitrile 2a, 3-aminoindole-2-carbonitrile 3a and (2-cyanoindol-3-yl)iminotriphenylphosphorane 4a, tog

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 5922-60-1