Acetic acid, [3-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy )carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]phenoxy]-, ethyl ester

Base Information

Chemical Name:Acetic acid, [3-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy )carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]phenoxy]-, ethyl ester
CAS No.:603122-15-2
Molecular Formula:C33H38ClNO7
Molecular Weight:596.12
Hs Code.:

Acetic acid,
[3-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy
)carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]phenoxy]-, ethyl
ester

Synonyms:

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Chemical Property of Acetic acid, [3-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy )carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]phenoxy]-, ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Acetic acid, [3-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy )carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]phenoxy]-, ethyl ester

There total 11 articles about Acetic acid, [3-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy )carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]phenoxy]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₂ClNO₅

: 105-36-2
ethyl bromoacetate

: 603122-15-2
{3-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-tert-butyloxycarbonylamino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]phenoxy}acetic acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;
DOI:10.1021/jm800222k

Reference yield:

: 132990-84-2
(2S)-N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

: 603122-15-2
{3-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-tert-butyloxycarbonylamino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]phenoxy}acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: boron tribromide / dichloromethane / 4 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h

3: ethanol / Reflux

4: tetrahydrofuran / 20 °C

5: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

7: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

With palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; copper diacetate; boron tribromide; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm800222k

Reference yield:

: 603122-70-9
(7S)-7-(benzylamino)-5,6,7,8-tetrahydronaphthalen-2-ol

: 603122-15-2
{3-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-tert-butyloxycarbonylamino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]phenoxy}acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 2 h

2: ethanol / Reflux

3: tetrahydrofuran / 20 °C

4: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

With palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; copper diacetate; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm800222k