Benzoic acid, 3-[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy) carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]-, methyl ester

Base Information

Chemical Name:Benzoic acid, 3-[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy) carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]-, methyl ester
CAS No.:603122-30-1
Molecular Formula:C31H34ClNO5
Molecular Weight:536.068
Hs Code.:

Benzoic acid,
3-[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy)
carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]-, methyl ester

Synonyms:

Suppliers and Price of Benzoic acid, 3-[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy) carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Benzoic acid, 3-[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy) carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Benzoic acid, 3-[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy) carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]-, methyl ester

There total 10 articles about Benzoic acid, 3-[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy) carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 603125-59-3
(7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate

: 99769-19-4
[3-(methoxycarbonyl)phenyl]boronic acid

: 603122-30-1
3-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-tert-butyloxycarbonylamino}-5,6,7,8-tetrahydro-2-naphthalenyl)benzoic acid methyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; at 20 - 80 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm800222k

Reference yield:

: 132990-84-2
(2S)-N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

: 603122-30-1
3-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-tert-butyloxycarbonylamino}-5,6,7,8-tetrahydro-2-naphthalenyl)benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: boron tribromide / dichloromethane / 4 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h

3: ethanol / Reflux

4: tetrahydrofuran / 20 °C

5: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C / Inert atmosphere

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water / 2 h / 20 - 80 °C / Inert atmosphere

With 2,6-dimethylpyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; boron tribromide; sodium carbonate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 6: Suzuki coupling;
DOI:10.1021/jm800222k

Reference yield:

: 603122-70-9
(7S)-7-(benzylamino)-5,6,7,8-tetrahydronaphthalen-2-ol

: 603122-30-1
3-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-tert-butyloxycarbonylamino}-5,6,7,8-tetrahydro-2-naphthalenyl)benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 2 h

2: ethanol / Reflux

3: tetrahydrofuran / 20 °C

4: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C / Inert atmosphere

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water / 2 h / 20 - 80 °C / Inert atmosphere

With 2,6-dimethylpyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 5: Suzuki coupling;
DOI:10.1021/jm800222k