(7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate

Base Information

Chemical Name:(7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate
CAS No.:603125-59-3
Molecular Formula:C₂₄H₂₇ClF₃NO₆S
Molecular Weight:549.996
Hs Code.:

Synonyms:(7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate

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Chemical Property of (7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate

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Technology Process of (7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate

There total 9 articles about (7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 121489-29-0
tert-butyl [(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(2S)-7-hydroxy-1,2,3,4-tetrahydro-2-naphthalenyl]carbamate

: 603125-59-3
(7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm800222k

Reference yield:

: 132990-84-2
(2S)-N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

: 603125-59-3
(7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: boron tribromide / dichloromethane / 4 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h

3: ethanol / Reflux

4: tetrahydrofuran / 20 °C

5: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C / Inert atmosphere

With 2,6-dimethylpyridine; palladium 10% on activated carbon; hydrogen; boron tribromide; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jm800222k

Reference yield:

: 603122-70-9
(7S)-7-(benzylamino)-5,6,7,8-tetrahydronaphthalen-2-ol

: 603125-59-3
(7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 2 h

2: ethanol / Reflux

3: tetrahydrofuran / 20 °C

4: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C / Inert atmosphere

With 2,6-dimethylpyridine; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jm800222k