Benzoic acid, 2-chloro-5-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimeth ylethoxy)carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-, methyl ester

Base Information

Chemical Name:Benzoic acid, 2-chloro-5-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimeth ylethoxy)carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-, methyl ester
CAS No.:603123-95-1
Molecular Formula:C31H33Cl2NO6
Molecular Weight:586.512
Hs Code.:

Benzoic acid,
2-chloro-5-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimeth
ylethoxy)carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-, methyl
ester

Synonyms:

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Chemical Property of Benzoic acid, 2-chloro-5-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimeth ylethoxy)carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-, methyl ester

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Technology Process of Benzoic acid, 2-chloro-5-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimeth ylethoxy)carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-, methyl ester

There total 9 articles about Benzoic acid, 2-chloro-5-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimeth ylethoxy)carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 874219-45-1
[3-(methoxycarbonyl)-4-chlorophenyl]boronic acid

: 121489-29-0
tert-butyl [(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(2S)-7-hydroxy-1,2,3,4-tetrahydro-2-naphthalenyl]carbamate

: 603123-95-1
C₃₁H₃₃Cl₂NO₆

Guidance literature:: With copper diacetate; triethylamine; In dichloromethane; at 20 ℃; Molecular sieve; Inert atmosphere;
DOI:10.1021/jm800222k

Reference yield:

: 132990-84-2
(2S)-N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

: 603123-95-1
C₃₁H₃₃Cl₂NO₆

Guidance literature:: Multi-step reaction with 5 steps

1: boron tribromide / dichloromethane / 4 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h

3: ethanol / Reflux

4: tetrahydrofuran / 20 °C

5: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

With palladium 10% on activated carbon; hydrogen; copper diacetate; boron tribromide; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jm800222k

Reference yield:

: 603122-70-9
(7S)-7-(benzylamino)-5,6,7,8-tetrahydronaphthalen-2-ol

: 603123-95-1
C₃₁H₃₃Cl₂NO₆

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 2 h

2: ethanol / Reflux

3: tetrahydrofuran / 20 °C

4: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

With palladium 10% on activated carbon; hydrogen; copper diacetate; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jm800222k