Benzoic acid, 3-(acetylamino)-5-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1 -dimethylethoxy)carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]- , methyl ester

Base Information

Chemical Name:Benzoic acid, 3-(acetylamino)-5-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1 -dimethylethoxy)carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]- , methyl ester
CAS No.:603124-62-5
Molecular Formula:C33H37ClN2O7
Molecular Weight:609.119
Hs Code.:

Benzoic acid,
3-(acetylamino)-5-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1
-dimethylethoxy)carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-
, methyl ester

Synonyms:

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Chemical Property of Benzoic acid, 3-(acetylamino)-5-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1 -dimethylethoxy)carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]- , methyl ester

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Technology Process of Benzoic acid, 3-(acetylamino)-5-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1 -dimethylethoxy)carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]- , methyl ester

There total 11 articles about Benzoic acid, 3-(acetylamino)-5-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1 -dimethylethoxy)carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]- , methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 603124-58-9
methyl 3-amino-5-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoate

: 108-24-7
acetic anhydride

: 603124-62-5
methyl 3-(acetylamino)-5-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoate

Guidance literature:: With pyridine; at 4 - 20 ℃; for 2h;
DOI:10.1021/jm800222k

Reference yield:

: 132990-84-2
(2S)-N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

: 603124-62-5
methyl 3-(acetylamino)-5-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: boron tribromide / dichloromethane / 4 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h

3: ethanol / Reflux

4: tetrahydrofuran / 20 °C

5: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

6: iron; ammonium chloride / ethanol; water / 2 h / Reflux

7: pyridine / 2 h / 4 - 20 °C

With pyridine; palladium 10% on activated carbon; hydrogen; copper diacetate; boron tribromide; iron; ammonium chloride; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1021/jm800222k

Reference yield:

: 603123-22-4
methyl 3-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-nitrobenzoate

: 603124-62-5
methyl 3-(acetylamino)-5-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: iron; ammonium chloride / ethanol; water / 2 h / Reflux

2: pyridine / 2 h / 4 - 20 °C

With pyridine; iron; ammonium chloride; In ethanol; water;
DOI:10.1021/jm800222k