Technology Process of 2-Propanone,
1-[1-(2-methoxy-5-methylphenyl)-2,2-dimethylcyclopentyl]-
There total 11 articles about 2-Propanone,
1-[1-(2-methoxy-5-methylphenyl)-2,2-dimethylcyclopentyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 72 percent / Li / tetrahydrofuran / 0.75 h
2.1: 91 percent / PCC; silica gel / CH2Cl2 / 2 h
3.1: 78 percent / tetrahydrofuran / 4 h
4.1: 84 percent / PCC; silica gel / CH2Cl2 / 24 h
5.1: 89 percent / NaBH4 / methanol / 0 - 5 °C
6.1: 30 percent / EtCOOH / 36 h / 180 °C
7.1: 88 percent / PhCH=RuCl2(PCy3)2 / CH2Cl2 / 6 h / 20 °C
8.1: 99 percent / H2 / Pd/C / ethanol / 6 h
9.1: 83 percent / diethyl ether / 4 h
10.1: POCl3 / pyridine / 0.5 h / -70 °C
10.2: O3; O2 / methanol; CH2Cl2 / -70 °C
With
sodium tetrahydroborate; hydrogen; silica gel; lithium; propionic acid; pyridinium chlorochromate; trichlorophosphate;
palladium on activated charcoal; Grubbs catalyst first generation;
In
tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; dichloromethane;
1.1: Barbier reaction / 6.1: Claisen rearrangement;
DOI:10.1016/S0040-4039(02)02734-X
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 72 percent / Li / tetrahydrofuran / 0.75 h
2.1: 91 percent / PCC; silica gel / CH2Cl2 / 2 h
3.1: 78 percent / tetrahydrofuran / 4 h
4.1: 84 percent / PCC; silica gel / CH2Cl2 / 24 h
5.1: 89 percent / NaBH4 / methanol / 0 - 5 °C
6.1: 30 percent / EtCOOH / 36 h / 180 °C
7.1: 88 percent / PhCH=RuCl2(PCy3)2 / CH2Cl2 / 6 h / 20 °C
8.1: 99 percent / H2 / Pd/C / ethanol / 6 h
9.1: 83 percent / diethyl ether / 4 h
10.1: POCl3 / pyridine / 0.5 h / -70 °C
10.2: O3; O2 / methanol; CH2Cl2 / -70 °C
With
sodium tetrahydroborate; hydrogen; silica gel; lithium; propionic acid; pyridinium chlorochromate; trichlorophosphate;
palladium on activated charcoal; Grubbs catalyst first generation;
In
tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; dichloromethane;
1.1: Barbier reaction / 6.1: Claisen rearrangement;
DOI:10.1016/S0040-4039(02)02734-X
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 78 percent / tetrahydrofuran / 4 h
2.1: 84 percent / PCC; silica gel / CH2Cl2 / 24 h
3.1: 89 percent / NaBH4 / methanol / 0 - 5 °C
4.1: 30 percent / EtCOOH / 36 h / 180 °C
5.1: 88 percent / PhCH=RuCl2(PCy3)2 / CH2Cl2 / 6 h / 20 °C
6.1: 99 percent / H2 / Pd/C / ethanol / 6 h
7.1: 83 percent / diethyl ether / 4 h
8.1: POCl3 / pyridine / 0.5 h / -70 °C
8.2: O3; O2 / methanol; CH2Cl2 / -70 °C
With
sodium tetrahydroborate; hydrogen; silica gel; propionic acid; pyridinium chlorochromate; trichlorophosphate;
palladium on activated charcoal; Grubbs catalyst first generation;
In
tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; dichloromethane;
4.1: Claisen rearrangement;
DOI:10.1016/S0040-4039(02)02734-X
