3-Hydroxy-5-Methylbenzaldehyde

Base Information

• Chemical Name: 3-Hydroxy-5-Methylbenzaldehyde
• CAS No.: 60549-26-0
• Molecular Formula: C8H8O2
• Molecular Weight: 136.15
• Hs Code.: 2912499000
• Mol file: 60549-26-0.mol

Synonyms:

Chemical Property of 3-Hydroxy-5-Methylbenzaldehyde

Chemical Property:

• Melting Point: 107-108 °C(Solv: chloroform (67-66-3))
• Boiling Point: 259.2±20.0 °C(Predicted)
• PKA: 9.35±0.10(Predicted)
• PSA: 37.30000
• Density: 1.175±0.06 g/cm3(Predicted)
• LogP: 1.51310
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

3-Hydroxy-5-methyl-benzaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Hydroxy-5-Methylbenzaldehyde

There total 4 articles about 3-Hydroxy-5-Methylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-Chloro-5-methylcyclohex-1-en-1-carbaldehyd (90003-09-1) → 3-hydroxy-5-methylbenzaldehyde (60549-26-0)

Guidance literature:

With oxygen; potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 20h;

Reference yield: 60.0%

3-methoxy-5-methyl-benzaldehyde (90674-26-3) → 3-hydroxy-5-methylbenzaldehyde (60549-26-0)

Guidance literature:

3-methoxy-5-methyl-benzaldehyde; With boron tribromide; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; acetic acid; In dichloromethane; water; for 10h; Reflux; Inert atmosphere;

DOI:10.1021/ja305113d

Reference yield:

(3-methoxy-5-methylphenyl)methanol (119650-44-1) → 3-hydroxy-5-methylbenzaldehyde (60549-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: silica gel; pyridinium chlorochromate / dichloromethane / 1 h / 20 °C

2.1: boron tribromide / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.2: 10 h / Reflux; Inert atmosphere

With silica gel; boron tribromide; pyridinium chlorochromate; In dichloromethane;

DOI:10.1021/ja305113d

upstream raw materials:

3-methoxy-5-methyl-benzaldehyde

(3-methoxy-5-methylphenyl)methanol

1-bromomethyl-3-methoxy-5-methyl-benzene

2-Chloro-5-methylcyclohex-1-en-1-carbaldehyd

Downstream raw materials:

2-(3-hydroxy-5-methylphenyl)-1,3-dioxane

3-methoxy-5-methyl-benzaldehyde

Refernces

• 1、 Tibrewal, Nidhi,Downey, Theresa E.,Van Lanen, Steven G.,Ul Sharif, Ehesan,O'Doherty, George A.,Rohr, Juergen. "Roles of the synergistic reductive O-methyltransferase GilM and of O-methyltransferase GilMT in the gilvocarcin biosynthetic pathway". supporting information; experimental part. p. 12402 - 12405. Retrieved 2012/09/05.