1-(BROMOMETHYL)-3-METHOXY-5-METHYLBENZENE

Base Information

• Chemical Name: 1-(BROMOMETHYL)-3-METHOXY-5-METHYLBENZENE
• CAS No.: 106116-42-1
• Molecular Formula: C9H11BrO
• Molecular Weight: 215.09
• Hs Code.: 2909309090
• Mol file: 106116-42-1.mol

Synonyms:1-bromomethyl-3-methoxy-5-methyl-benzene;3-Methoxy-5-methylbenzylbromid;3-methoxy-5-methylbenzyl bromide;

Chemical Property of 1-(BROMOMETHYL)-3-METHOXY-5-METHYLBENZENE

Chemical Property:

• PSA: 9.23000
• LogP: 2.89850
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

1-Bromomethyl-3-methoxy-5-methylbenzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(BROMOMETHYL)-3-METHOXY-5-METHYLBENZENE

There total 5 articles about 1-(BROMOMETHYL)-3-METHOXY-5-METHYLBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3,5-dimethylmethoxybenzene (874-63-5) → 1-bromomethyl-3-methoxy-5-methyl-benzene (106116-42-1)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 1h; Heating;

DOI:10.1055/s-2006-950355

Reference yield: 67.0%

3,5-dimethylmethoxybenzene (874-63-5) → 2-bromo-5-methoxy-1,3-dimethyl-benzene (6267-34-1) + 1-bromomethyl-3-methoxy-5-methyl-benzene (106116-42-1)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 1h; Heating; irradiation;

DOI:10.1071/CH99093

Reference yield: 35.0%

3,5-dimethylmethoxybenzene (874-63-5) → 3,5-bis(bromomethyl)anisole (19254-79-6) + 1-bromomethyl-3-methoxy-5-methyl-benzene (106116-42-1)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 14h; Heating; irradiation;

DOI:10.1021/jo990776m

upstream raw materials:

3,5-dimethylmethoxybenzene

azobisisobutyronitrile

Downstream raw materials:

3-methoxy-5-methyl-benzaldehyde

6,7-dimethoxy-1-(3-methoxy-5-methyl-benzyl)-3,4-dihydro-isoquinoline-4-carboxylic acid ethyl ester

6,7-dimethoxy-1-(3-methoxy-5-methyl-benzyl)-isoquinoline-4-carboxylic acid ethyl ester

2-(3,4-dimethoxy-phenyl)-3-[2-(3-methoxy-5-methyl-phenyl)-acetylamino]-propionic acid ethyl ester

Refernces

• 1、 Yamaguchi, Sho,Tanaka, Hiroshi,Yamada, Ryo,Kawauchi, Susumu,Takahashi, Takashi. "Synthesis of a landomycinone skeleton via Masamune-Bergmann cyclization". . p. 32241 - 32248. Retrieved 2014.
• 2、 Jorgensen, William L.,Bollini, Mariela,Thakur, Vinay V.,Domaoal, Robert A.,Spasov, Krasimir A.,Anderson, Karen S.. "Efficient discovery of potent anti-HIV agents targeting the Tyr181Cys variant of HIV reverse transcriptase". supporting information; scheme or table. p. 15686 - 15696. Retrieved 2011/12/03.