3-Pyridinecarboxylic acid, 2-[(4-methylphenyl)amino]-

Base Information

• Chemical Name: 3-Pyridinecarboxylic acid, 2-[(4-methylphenyl)amino]-
• CAS No.: 60645-32-1
• Molecular Formula: C13H12N2O2
• Molecular Weight: 228.24700

Synonyms:2-(p-tolylamino)nicotinic acid;2-p-Tolylamino-nicotinic acid;2-(p-toluidino)-3-pyridinecarboxylic acid;

Chemical Property of 3-Pyridinecarboxylic acid, 2-[(4-methylphenyl)amino]-

Chemical Property:

• Melting Point: 203 - 204 °C (water)
• PSA: 62.22000
• LogP: 2.90480

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Toluidino)nicotinic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 3-Pyridinecarboxylic acid, 2-[(4-methylphenyl)amino]-

There total 2 articles about 3-Pyridinecarboxylic acid, 2-[(4-methylphenyl)amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-chloronicotinic acid (2942-59-8) + p-toluidine (106-49-0,12221-03-3) → 2-[(4-methylphenyl)amino]pyridine-3-carboxylic acid (60645-32-1)

Guidance literature:

With potassium carbonate; In water; at 150 ℃; for 2.5h; Green chemistry;

DOI:10.1007/s11164-012-0494-0

Reference yield: 21.0%

ethyl acetoacetate (141-97-9) + 1-p-tolylpyrimidin-2(1H)-one (17758-14-4) → 2-[(4-methylphenyl)amino]pyridine-3-carboxylic acid (60645-32-1)

Guidance literature:

With sodium ethanolate; In ethanol; for 2h; Ambient temperature;

upstream raw materials:

ethyl acetoacetate

1-p-tolylpyrimidin-2(1H)-one

2-chloronicotinic acid

p-toluidine

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