5,12-Naphthacenedione, 9-acetyl-7-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, (7R-cis)-

Base Information

Chemical Name:5,12-Naphthacenedione, 9-acetyl-7-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, (7R-cis)-
CAS No.:58957-91-8
Molecular Formula:C₂₆H₂₇NO₉
Molecular Weight:497.502
Hs Code.:

Synonyms:5,12-Naphthacenedione, 9-acetyl-7-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, (7R-cis)-;4-Demethoxy-7,9-di-epi-daunorubicin;PD062679;(7R-cis)-9-Acetyl-7-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione

Suppliers and Price of 5,12-Naphthacenedione, 9-acetyl-7-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, (7R-cis)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5,12-Naphthacenedione, 9-acetyl-7-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, (7R-cis)-

Chemical Property:

Vapor Pressure:4.34E-22mmHg at 25°C
Boiling Point:725.4°C at 760 mmHg
PKA:7.79±0.60(Predicted)
Flash Point:392.5°C
Density:1.56g/cm³
XLogP3:1.9
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:3
Exact Mass:497.16858144
Heavy Atom Count:36
Complexity:912

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=CC=CC=C5C4=O)O)(C(=O)C)O)N)O
Isomeric SMILES:C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=CC=CC=C5C4=O)O)(C(=O)C)O)N)O

Technology Process of 5,12-Naphthacenedione, 9-acetyl-7-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, (7R-cis)-

There total 22 articles about 5,12-Naphthacenedione, 9-acetyl-7-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, (7R-cis)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60660-74-4
(+)-N-Trifluoroacetyl-4-demethoxydaunorubicin

: 58957-92-9,58957-91-8,58957-93-0
idarubicin

Guidance literature:: With sodium hydroxide; In water; for 0.5h; Ambient temperature;

Reference yield:

: 1403872-37-6
4-demethoxy-3'-N₃-daunorubicin

: 58957-92-9,58957-91-8,58957-93-0
idarubicin

Guidance literature:: 4-demethoxy-3'-N₃-daunorubicin; With triphenylphosphine; In tetrahydrofuran;

With ammonia; In tetrahydrofuran;

Reference yield:

: 23541-50-6
daunomycin hydrochloride

: 58957-92-9,58957-91-8,58957-93-0
idarubicin

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; triflic azide / dichloromethane; water; methanol

2.1: potassium iodide; magnesium chloride / tetrahydrofuran / 1.5 h / 40 °C

2.2: pH 2.5 / Cooling with ice

3.1: N-ethyl-N,N-diisopropylamine; pyridine / dmap / 1 h / 0 - 20 °C

4.1: triethylammonium formate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 8 h / 50 °C / Inert atmosphere

5.1: triphenylphosphine / tetrahydrofuran

With pyridine; triflic azide; triethylammonium formate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium iodide; magnesium chloride; dmap; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;