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(+)-N-Trifluoroacetyl-4-demethoxydaunorubicin, also known as TF3, is a synthetic derivative of the chemotherapy drug daunorubicin. It is characterized by the addition of a trifluoroacetyl group to the daunorubicin molecule, which enhances its stability and bioavailability. This modification makes TF3 more effective in targeting cancer cells due to its unique chemical structure and pharmaceutical properties.

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  • 60660-74-4 Structure
  • Basic information

    1. Product Name: (+)-N-Trifluoroacetyl-4-demethoxydaunorubicin
    2. Synonyms: (+)-N-Trifluoroacetyl-4-demethoxydaunorubicin
    3. CAS NO:60660-74-4
    4. Molecular Formula:
    5. Molecular Weight: 593.51
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 60660-74-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (+)-N-Trifluoroacetyl-4-demethoxydaunorubicin(CAS DataBase Reference)
    10. NIST Chemistry Reference: (+)-N-Trifluoroacetyl-4-demethoxydaunorubicin(60660-74-4)
    11. EPA Substance Registry System: (+)-N-Trifluoroacetyl-4-demethoxydaunorubicin(60660-74-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 60660-74-4(Hazardous Substances Data)

60660-74-4 Usage

Uses

Used in Oncology:
TF3 is utilized as an anticancer agent for the treatment of various types of cancer, such as leukemia, lymphoma, and solid tumors. Its mechanism of action involves inhibiting the growth of cancer cells and inducing cell death, which contributes to its therapeutic efficacy.
Additionally, TF3 may possess anti-angiogenic properties, which could further enhance its potential in cancer treatment by preventing the formation of new blood vessels that supply nutrients to tumors.
Due to its promising characteristics, TF3 is considered a valuable candidate for the development of new and improved cancer treatments, potentially offering more effective and targeted therapies for patients.

Check Digit Verification of cas no

The CAS Registry Mumber 60660-74-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,6,6 and 0 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 60660-74:
(7*6)+(6*0)+(5*6)+(4*6)+(3*0)+(2*7)+(1*4)=114
114 % 10 = 4
So 60660-74-4 is a valid CAS Registry Number.

60660-74-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name (+)-N-Trifluoroacetyl-4-demethoxydaunorubicin

1.2 Other means of identification

Product number -
Other names 4-demethoxy-3'-trifluoroacetamido-daunorubicine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:60660-74-4 SDS

60660-74-4Relevant articles and documents

Total Synthesis of 4-Demethoxydaunomycin

Broadhurst, Michael J.,Hassall, Cedric H.,Thomas, Gareth J.

, p. 158 - 160 (1982)

The Diels-Alder adduct prepared from the optically active, fully functionalised bicyclic precursor (8) and o-benzoquinone dimethide has been converted in good yield inmto (+)-4-demethoxydaunomycinone (13), glycosidation of which with the daunosamine derivative (14) gives 4-demethoxydaunomycin.

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