N,N-Dibutyl-4-phenylbutanamide

Base Information

• Chemical Name: N,N-Dibutyl-4-phenylbutanamide
• CAS No.: 61123-41-9
• Molecular Formula: C18H29NO
• Molecular Weight: 275.434
• DSSTox Substance ID: DTXSID20440848
• Wikidata: Q82257288
• Mol file: 61123-41-9.mol

Synonyms:N,N-DIBUTYL-4-PHENYLBUTANAMIDE;61123-41-9;DTXSID20440848

Chemical Property of N,N-Dibutyl-4-phenylbutanamide

Chemical Property:

• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 10
• Exact Mass: 275.224914549
• Heavy Atom Count: 20
• Complexity: 238

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCN(CCCC)C(=O)CCCC1=CC=CC=C1

Technology Process of N,N-Dibutyl-4-phenylbutanamide

There total 4 articles about N,N-Dibutyl-4-phenylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

dibutylamine (111-92-2) + 4-Phenylbutyric acid (1821-12-1) → N,N-Dibutyl-4-phenyl-butyramide (61123-41-9)

Guidance literature:

With 3,4,5-trifluorophenylboronic acid; In 1,3,5-trimethyl-benzene; for 14.5h; Heating; other solvent;

DOI:10.1021/jo9606564

Reference yield: 66.0%

dibutylamine (111-92-2) + phenylbutyric acid chloride (18496-54-3) → N,N-Dibutyl-4-phenyl-butyramide (61123-41-9)

Guidance literature:

With triethylamine;

DOI:10.1021/je00038a033

Reference yield: 38.0%

N,N-diethyl-4-phenylbutanamide (56229-85-7) + dibutylamine (111-92-2) → N,N-Dibutyl-4-phenyl-butyramide (61123-41-9)

Guidance literature:

With chloro-trimethyl-silane; 1,10-Phenanthroline; tungsten(VI) chloride; In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 36h;

DOI:10.1021/acscatal.1c01840

upstream raw materials:

dibutylamine

phenylbutyric acid chloride

4-Phenylbutyric acid

N,N-diethyl-4-phenylbutanamide

Downstream raw materials:

N-phenyl-4-phenylbutyramide