Chemical Property of 6,7-Dimethoxy-2-phenylquinoxaline
Chemical Property:
- Vapor Pressure:6.97E-07mmHg at 25°C
- Boiling Point:420.2°Cat760mmHg
- PKA:0.48±0.30(Predicted)
- Flash Point:151.8°C
- PSA：44.24000
- Density:1.192g/cm3
- LogP:3.31400
- Storage Temp.:2-8°C
- Sensitive.:Light Sensitive
- Solubility.:Soluble in DMSO.
- XLogP3:2.8
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:3
- Exact Mass:266.105527694
- Heavy Atom Count:20
- Complexity:307
- Purity/Quality:
-
97% *data from raw suppliers
Tyrphostin AG-1296 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:COC1=C(C=C2C(=C1)N=CC(=N2)C3=CC=CC=C3)OC
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Description
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the treatment of atherosclerosis, restenosis, pulmonary fibrosis, and gliomas. AG-1296 is a potent and selective inhibitor of PDGF receptor kinase with an IC50 value of about 0.4 μM both in vitro and in cells (Swiss 3T3 cells). It inhibits ligand-stimulated DNA synthesis in platelet-derived growth factor receptor and stem cell factor/kit receptor transfected cells with an IC50 values of 1.5 and 1.8 μM, respectively. Treatment of sis oncogene transfected NIH3T3 cells with AG-1296 reverses the transformed phenotype.
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Uses
Tyrphostin AG 1296, is the platelet-derived growth factor receptor (PDGFR) inhibitor, which can causes growth inhibition in glioblastoma cells.
