2-CHLORO-N-[4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]ACETAMIDE

Base Information

• Chemical Name: 2-CHLORO-N-[4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]ACETAMIDE
• CAS No.: 6125-31-1
• Molecular Formula: C11H8Cl2N2OS
• Molecular Weight: 287.169
• Hs Code.: 2934100090
• Mol file: 6125-31-1.mol

Synonyms:2-chloro-N-m-tolylacetamide;2-Chloracetylamino-4-<4-chlor-phenyl>-thiazol;

Chemical Property of 2-CHLORO-N-[4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]ACETAMIDE

Chemical Property:

• PSA: 70.23000
• LogP: 3.71380

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-acetamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-N-[4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]ACETAMIDE

There total 4 articles about 2-CHLORO-N-[4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(4-chlorophenyl)-2-thiazolamine (2103-99-3) + chloroacetyl chloride (79-04-9) → 2-chloro-N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]acetamide (6125-31-1)

Guidance literature:

4-(4-chlorophenyl)-2-thiazolamine; With triethylamine; In dichloromethane; at 0 - 5 ℃; for 0.5h;

chloroacetyl chloride; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.24820/ark.5550190.p010.534

Reference yield:

para-chloroacetophenone (99-91-2) → 2-chloro-N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]acetamide (6125-31-1)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(ll) bromide / ethanol; chloroform; ethyl acetate / 0.5 h / 65 °C

2: ethanol / 2 h / Reflux

3: triethylamine / N,N-dimethyl-formamide / 10 °C

With triethylamine; copper(ll) bromide; In ethanol; chloroform; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2012.03.006

Reference yield:

4-chlorobenzoylmethyl bromide (536-38-9) → 2-chloro-N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]acetamide (6125-31-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 2 h / Reflux

2: triethylamine / N,N-dimethyl-formamide / 10 °C

With triethylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2012.03.006

upstream raw materials:

4-(4-chlorophenyl)-2-thiazolamine

chloroacetyl chloride

p-chlorophenacyl chloride

para-chloroacetophenone

Downstream raw materials:

'-Piperidinoacetylamino-4-<4-chlor-phenyl>-thiazol

N,N'-bis-[4-(4-chloro-phenyl)-thiazol-2-yl]-2,2'-piperazine-1,4-diyl-bis-acetamide

N-benzyl-N-phenyl-glycine 4-(4-chloro-phenyl)-thiazol-2-ylamide

2-benzoimidazol-1-yl-N-[4-(4-chloro-phenyl)-thiazol-2-yl]-acetamide

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