Technology Process of [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [(3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphono phosphate
There total 4 articles about [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [(3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphono phosphate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5'-adenosine monophosphate bis-(tri-n-butylammonium) salt;
With
1,1'-carbonyldiimidazole;
In
N,N-dimethyl-formamide;
at 20 ℃;
Inert atmosphere;
tributylammonium uridine-5′-monophosphate;
In
methanol; N,N-dimethyl-formamide;
at 20 ℃;
Inert atmosphere;
DOI:10.1039/c005122e
- Guidance literature:
-
With
acetonitrile; benzene;
beim Erwaermen des erhaltenen Reaktionsprodukts mit Kaliumthiocyanat in Butanon und anschliessenden Behandeln mit wss. HCl;
- Guidance literature:
-
With
pyridine; dicyclohexyl-carbodiimide;