Adenosine Phosphate

Base Information

• Chemical Name: Adenosine Phosphate
• CAS No.: 61-19-8
• Deprecated CAS: 162756-82-3,47286-65-7,47287-97-8,53624-78-5,67583-85-1,697214-87-2,47286-65-7,47287-97-8,53624-78-5,67583-85-1
• Molecular Formula: C10H14N5O7P
• Molecular Weight: 347.224
• Hs Code.: HOSPHATE PRODUCT IDENTIFICATION
• European Community (EC) Number: 200-500-0
• UNII: 415SHH325A
• DSSTox Substance ID: DTXSID5022560
• Nikkaji Number: J4.814C
• Wikipedia: Adenosine_monophosphate
• Wikidata: Q318369
• NCI Thesaurus Code: C83606
• RXCUI: 309
• Pharos Ligand ID: HV8WVK8BQSW2
• Metabolomics Workbench ID: 37043
• ChEMBL ID: CHEMBL752
• Mol file: 61-19-8.mol

Synonyms:2' Adenosine Monophosphate;2' Adenylic Acid;2'-adenosine monophosphate;2'-adenylic acid;2'-AMP;5' Adenylic Acid;5'-Adenylic Acid;5'-Phosphate, Adenosine;Acid, 2'-Adenylic;Acid, 5'-Adenylic;Adenosine 2' Phosphate;Adenosine 2'-Phosphate;Adenosine 3' Phosphate;Adenosine 3'-Phosphate;Adenosine 5' Phosphate;Adenosine 5'-Phosphate;Adenosine Monophosphate;Adenosine Phosphate Dipotassium;Adenosine Phosphate Disodium;Adenylic Acid;AMP;Dipotassium, Adenosine Phosphate;Disodium, Adenosine Phosphate;Monophosphate, 2'-Adenosine;Phosphaden;Phosphate Dipotassium, Adenosine;Phosphate Disodium, Adenosine

Chemical Property of Adenosine Phosphate

Chemical Property:

• Appearance/Colour: colorless to white crystalline powder
• Melting Point: 178-185 °C
• Boiling Point: 798.518 °C at 760 mmHg
• PKA: 3.8, 6.2(at 25℃)
• Flash Point: 436.728 °C
• PSA: 195.88000
• Density: 2.32 g/cm³
• LogP: -1.28180
• Storage Temp.: −20°C
• Solubility.: H2O: with addition of mild alkalisoluble
• Water Solubility.: Soluble in water.
• XLogP3: -3.5
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 4
• Exact Mass: 347.06308480
• Heavy Atom Count: 23
• Complexity: 481

Purity/Quality:

≥98% ^*data from raw suppliers

Adenosine5''-Monophosphate ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O)N
• Isomeric SMILES: C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)N
• Recent ClinicalTrials: Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults
• Recent EU Clinical Trials: Optimized pharmacological treatment for broken heart (takotsubo) syndrome
• Description: Adenosine-5'-monophosphoric acid is a nucleotide that is synthesized from adenosine triphosphate and inosine monophosphate. Adenosine-5'-monophosphoric acid is an important molecule in the body because it is a substrate for cyclic AMP, which regulates many cellular processes. Adenosine-5'-monophosphoric acid also has biochemical properties that are similar to those of the neurotransmitter serotonin and it can activate the 5-HT2 receptors.
• Uses: vasodilator, neuromodulator A useful ligand determinant that facilitates the binding of APS reductase inhibitors. Adenosine 5'-monophosphate is a nucleotide (building blocks of nucleic acid) added to skin care products to bind water and moisture.

Technology Process of Adenosine Phosphate

There total 211 articles about Adenosine Phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

adenosine-5'-monophosphate disodium salt (4578-31-8) → 5'-adenosine monophosphate (61-19-8,24937-83-5,67583-85-1)

Guidance literature:

With Dowex 50W×8 resin; In water; at 20 ℃; for 0.5h;

DOI:10.1021/acs.orglett.6b00311

Reference yield: 99.0%

5,6-dimethyl-1H-benzotriazole adenine dinucleotide ammonium salt → 5,6-dimethyl-1H-benzotriazole mononucleotide ammonium salt (123499-60-5) + 5'-adenosine monophosphate (61-19-8,24937-83-5,67583-85-1)

Guidance literature:

With phosphodiesterase; tris hydrochloride; magnesium chloride; In water; at 37 ℃; for 5h; pH: 9.0;

Reference yield: 98.0%

5-methyl-1H-benzotriazole adenine dinucleotide ammonium salt → 5-methyl-1H-benzotriazole mononucleotide ammonium salt (123499-59-2) + 5'-adenosine monophosphate (61-19-8,24937-83-5,67583-85-1)

Guidance literature:

With phosphodiesterase; tris hydrochloride; magnesium chloride; In water; at 37 ℃; for 10h; pH: 9.0;

upstream raw materials:

cAMP

L-Aspartic acid

[5']inosinic acid

2',3'-di-O-acetyladenosine

Downstream raw materials:

Phosphoric acid mono-[(2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester; compound with N,N'-dicyclohexyl-morpholine-4-carboxamidine

<2-13C>-adenosine 5'-monophosphate

6-<3-(4-sulfophenyl)-2-triazen-1-yl>purine ribonucleoside 5'-phosphate

C₁₇H₂₀N₇O₇P

Refernces

• 1、 Dykstra, Holly,Fisk, Chelsea,LaRose, Cassi,Waldhart, Althea,Meng, Xing,Zhao, Gongpu,Wu, Ning. "Mouse long-chain acyl-CoA synthetase 1 is active as a monomer". . . Retrieved 2021/02/01.
• 2、 Kaur, Rajinder,Saini, Sanjeev,Kaur, Navneet,Singh, Narinder,Jang, Doo Ok. "Rhodamine-based fluorescent probe for sequential detection of Al3+ ions and adenosine monophosphate in water". . . Retrieved 2019/09/16.