1-(((2-Chloroethyl)nitrosoamino)carbonyl)-L-prolyl-N-(2-chloroethyl)-L-leucinamide

Base Information

Chemical Name:1-(((2-Chloroethyl)nitrosoamino)carbonyl)-L-prolyl-N-(2-chloroethyl)-L-leucinamide
CAS No.:83472-46-2
Molecular Formula:C₁₆H₂₇Cl₂N₅O₄
Molecular Weight:424.327
Hs Code.:
DSSTox Substance ID:DTXSID701003452

Synonyms:BRN 5651606;1-(((2-Chloroethyl)nitrosoamino)carbonyl)-L-prolyl-N-(2-chloroethyl)-L-leucinamide;L-Leucinamide, 1-(((2-chloroethyl)nitrosoamino)carbonyl)-L-prolyl-N-(2-chloroethyl)-;N-(Chloro-2 ethyl) N-nitrosocarbamoyl L-prolyl L-leucine chloro-2 ethylamide [French];83472-46-2;N-(Chloro-2 ethyl) N-nitrosocarbamoyl L-prolyl L-leucine chloro-2 ethylamide;C16H27Cl2N5O4;DTXSID701003452;C16-H27-Cl2-N5-O4;LS-87793;2-[(2-Chloroethyl)amino]-N-{1-[(2-chloroethyl)(nitroso)carbamoyl]prolyl}-4-methylpentanimidic acid

Suppliers and Price of 1-(((2-Chloroethyl)nitrosoamino)carbonyl)-L-prolyl-N-(2-chloroethyl)-L-leucinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-(((2-Chloroethyl)nitrosoamino)carbonyl)-L-prolyl-N-(2-chloroethyl)-L-leucinamide

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.39g/cm³
XLogP3:1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:423.1440097
Heavy Atom Count:27
Complexity:535

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC(C(=O)NC(=O)C1CCCN1C(=O)N(CCCl)N=O)NCCCl
Isomeric SMILES:CC(C)C[C@@H](C(=O)NC(=O)[C@@H]1CCCN1C(=O)N(CCCl)N=O)NCCCl

Technology Process of 1-(((2-Chloroethyl)nitrosoamino)carbonyl)-L-prolyl-N-(2-chloroethyl)-L-leucinamide

There total 5 articles about 1-(((2-Chloroethyl)nitrosoamino)carbonyl)-L-prolyl-N-(2-chloroethyl)-L-leucinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 80354-51-4
N-(chloro-2 ethyl)N-nitrosocarbamate de trichloro-2,4,5 phenyle

: chlorhydrate de L-prolyl L-leucine chloro-2 ethylamide

: 83472-46-2
N-(chloro-2-ethyl) N-nitrosocarbamoyl L-prolyl L-leucine chloro-2 ethylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 2h; Ambient temperature;

Reference yield:

: 3397-35-1
Z-L-leucine hydroxysuccinimide ester

: 83472-46-2
N-(chloro-2-ethyl) N-nitrosocarbamoyl L-prolyl L-leucine chloro-2 ethylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / N,N-diisopropyl N-ethylamine / dimethylformamide / 2 h / Ambient temperature

2: H₂, cc. HCl / Pd/C / ethanol / 5 h

3: N,N-diisopropyl N-ethylamine / dimethylformamide / 2 h / Ambient temperature

4: 98 percent / H₂, cc. HCl / Pd/C / ethanol / 5 h

5: 75 percent / N,N-diisopropyl N-ethylamine / dimethylformamide / 2 h / Ambient temperature

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 83510-60-5
N-benzyloxycarbonylleucine (2-chloroethyl)amide

: 83472-46-2
N-(chloro-2-ethyl) N-nitrosocarbamoyl L-prolyl L-leucine chloro-2 ethylamide

Guidance literature:: Multi-step reaction with 4 steps

1: H₂, cc. HCl / Pd/C / ethanol / 5 h

2: N,N-diisopropyl N-ethylamine / dimethylformamide / 2 h / Ambient temperature

3: 98 percent / H₂, cc. HCl / Pd/C / ethanol / 5 h

4: 75 percent / N,N-diisopropyl N-ethylamine / dimethylformamide / 2 h / Ambient temperature

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;