80354-51-4

Usage

Uses

Used in Agricultural Applications:
2,4,5-Trichlorophenyl (2-chloroethyl)nitrosocarbamate is used as a herbicidal agent for the selective control of a wide range of annual broadleaf and grassy weeds in various crops such as soybeans, peanuts, and cotton. It is applied to effectively manage weed populations that compete with these crops for resources, thereby enhancing crop yield and quality.
Used in Environmental Management:
While the primary use of 2,4,5-trichlorophenyl (2-chloroethyl)nitrosocarbamate is in agriculture, its application also has implications for environmental management. It is crucial to follow safety guidelines and best practices in its use to mitigate the risk of harmful effects on non-target organisms, particularly aquatic life, and to prevent contamination of water bodies and soil.
Used in Safety Precautions:
Given its potential toxicity and irritancy, 2,4,5-trichlorophenyl (2-chloroethyl)nitrosocarbamate is also used as a reminder of the importance of safety precautions in agricultural and chemical handling contexts. This includes the use of personal protective equipment to prevent skin, eye, and respiratory system irritation, as well as the implementation of measures to minimize the chemical's impact on the environment.

Upstream product

• 95-95-4 2,4,5-trichlorophenol 
• 80354-46-7 2,4,5-trichlorophenyl N-(2-chloroethyl)carbamate 

Downstream Products

• 70866-07-8 N₁-(2-chloroethyl)-N₃-glucosamino-N₁-nitrosourea 
• 77469-44-4 bis N,N'-cystamine 
• 83472-40-6 N-(chloro-2 ethyl) N-nitrosocarbamoyl L-prolyl L-leucinamide 
• 83472-46-2 N-(chloro-2-ethyl) N-nitrosocarbamoyl L-prolyl L-leucine chloro-2 ethylamide 
• 83472-50-8 N-(chloro-2 ethyl) N-nitrosocarbamoyl L-prolyl L-leucyl glycine chloro-2 ethylamide 
• 83472-41-7 N-(chloro-2-ethyl) N-nitrosocarbamoyl L-prolyl L-leucyl glycinamide 
• 90764-39-9 (2-chloroethyl)nitrosourea phenylalanine (2-chloroethyl)amide 
• 96846-29-6 ethyl N³-<(2-chloroethyl)nitrosocarbamoyl>-N²-<4-<<(2,4-diamino-6-pteridinyl)methyl>methylamino>benzoyl>-2,3-diaminopropanoate 
• 90764-45-7 (2-chloroethyl)nitrosoureatyrosine (2-chloroethyl)amide 
• 13010-47-4 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea 
• 164120-30-3 7β-(2-chloroethyl-N-nitroso-N-carbonylamino)cholesterol 
• 164120-27-8 7β-<2-(N-(2-chloroethyl)-N-nitroso-N-carbonyl)amino(hydroxymethyl)ethyl>cholesterol 
• 164120-28-9 7α-(2-chloroethyl-N-nitroso-N-carbonylaminomethyl)cholesterol 
• 164120-28-9 7β-(2-chloroethyl-N-nitroso-N-carbonylaminomethyl)cholesterol 

Relevant academic research and scientific papers

Synthesis and preliminary in vitro evaluation of antitumor nitrosoureido cholesterol derivatives

A new class of chloroethyl nitrosourea analogues of cholesterol has been synthetized from the corresponding 7-amino and 7-aminoalkylcholesterol derivatives. Compounds III-V inhibited L1210 cell growth in culture much more effectively than N,N'-bis(2-cgloroethyl)-N'-nitrosourea (BCNU) after 48 h incubation. Stability and cytotoxic activity of these prodrugs are promising for brain tumor treatments and as lymphotropic vectors for tumor cells spreading along the lymphatic pathways.

Activated N-Nitrosocarbamates for Regioselective Synthesis of N-Nitrosoureas

A practical and convenient method for synthesizing antitumor compounds, N-alkyl-N-nitrosoureas, regioselectively nitrosated on the nitrogen atom bearing the alkyl group is proposed.N-Alkyl-N-nitrosocarbamates are interesting intermediates in these syntheses and yield, by reaction with amino compounds, the regioselectively nitrosated N-alkyl-N-nitrosoureas.As an interesting example, N,N'-biscystamine, a new attractive oncostatic derivative, has been prepared.The cytotoxic activity of these various compounds were tested on L1210 leukemia.