Methyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:Methyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate
CAS No.:618387-12-5
Molecular Formula:C7H13NO3
Molecular Weight:159.18300
Hs Code.:
DSSTox Substance ID:DTXSID80554915
Metabolomics Workbench ID:65285
Wikidata:Q27139125
Mol file:618387-12-5.mol

Synonyms:methyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate;618387-12-5;CHEBI:70831;DTXSID80554915;AKOS010669022;1-methoxycarbonyl-2-hydroxymethylpyrrolidine;Q27139125

Suppliers and Price of Methyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of Methyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate

Chemical Property:

PSA：49.77000
LogP:0.14740
XLogP3:0
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:159.08954328
Heavy Atom Count:11
Complexity:149

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)N1CCCC1CO

Technology Process of Methyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate

There total 3 articles about Methyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 83541-81-5
(S)-dimethyl pyrrolidine-1,2-dicarboxylate

: 618387-12-5
1-methoxycarbonyl-2-hydroxymethylpyrrolidine

Guidance literature:: With sodium tetrahydroborate; In methanol; tert-butyl alcohol; for 0.5h; Heating; ultrasonic irradiation;
DOI:10.1007/BF00532039

Reference yield: 83.0%

: O-methyl S-(pyridin-2-yl)carbonothioate

: 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol

: 618387-12-5
1-methoxycarbonyl-2-hydroxymethylpyrrolidine

Guidance literature:: In dichloromethane; at 20 ℃; chemoselective reaction;
DOI:10.1055/s-0039-1690856

Reference yield:

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 618387-12-5
1-methoxycarbonyl-2-hydroxymethylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: N(C₂H₅)3 / tetrahydrofuran / 1 h / Ambient temperature

2: 100 percent / NaBH₄ / methanol; 2-methyl-propan-2-ol / 0.5 h / Heating; ultrasonic irradiation

With sodium tetrahydroborate; triethylamine; In tetrahydrofuran; methanol; tert-butyl alcohol;
DOI:10.1007/BF00532039