N-(3-bromopyridin-2-yl)benzamide

Base Information

• Chemical Name: N-(3-bromopyridin-2-yl)benzamide
• CAS No.: 620939-76-6
• Molecular Formula: C12H9BrN2O
• Molecular Weight: 277.11700
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID20406641
• Wikidata: Q82211707
• Mol file: 620939-76-6.mol

Synonyms:N-(3-bromopyridin-2-yl)benzamide;620939-76-6;DTXSID20406641;AKOS002735319

Chemical Property of N-(3-bromopyridin-2-yl)benzamide

Chemical Property:

• PSA: 45.48000
• LogP: 3.48040
• Storage Temp.: 2-8°C
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 275.98983
• Heavy Atom Count: 16
• Complexity: 241

Purity/Quality:

98%Min ^*data from raw suppliers

N-(3-Bromopyridin-2-yl)benzamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)NC2=C(C=CC=N2)Br

Technology Process of N-(3-bromopyridin-2-yl)benzamide

There total 1 articles about N-(3-bromopyridin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-Amino-3-bromopyridine (13534-99-1) + benzoyl chloride (98-88-4) → N-(3-bromopyridin-2-yl)-2-benzamide (620939-76-6)

Guidance literature:

In pyridine; at 10 ℃; for 1h;

DOI:10.1055/s-2003-41052

Reference yield: 72.0%

N-(3-bromopyridin-2-yl)-2-benzamide (620939-76-6) → N'-(3-hydroxypyridin-2-yl)benzenecarboximidamide (634202-39-4)

Guidance literature:

With sodium amide; sodium t-butanolate; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1055/s-2003-41052

Reference yield: 25.0%

N-Methoxy-N-methylacetamide (78191-00-1) + N-(3-bromopyridin-2-yl)-2-benzamide (620939-76-6) → N-(3-acetylpyridin-2-yl)benzamide

Guidance literature:

N-(3-bromopyridin-2-yl)-2-benzamide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

N-Methoxy-N-methylacetamide; In tetrahydrofuran; hexane; at -30 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/jm5007947

upstream raw materials:

2-Amino-3-bromopyridine

benzoyl chloride

Downstream raw materials:

N'-(3-hydroxypyridin-2-yl)benzenecarboximidamide

2-phenyl[1,3]oxazolo[4,5-b]pyridine

2-phenyl-1,4-dihydro-1,8-naphthyridin-4-one

N-methyl-N-phenyl-2-[(2-phenyl-1,8-naphthyridin-4-yl)oxy]propanamide