Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-, ethyl ester

Base Information

• Chemical Name: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-, ethyl ester
• CAS No.: 623152-11-4
• Molecular Formula: C21H23N5O3
• Molecular Weight: 393.445
• Mol file: 623152-11-4.mol

Synonyms:

Chemical Property of Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-, ethyl ester

There total 4 articles about Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-chloro-5-methyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester (427878-41-9) + 3-amino-N-cyclopropyl-4-methyl-benzamide hydrochloride (623155-66-8) → ethyl 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxylate (623152-11-4)

Guidance literature:

4-chloro-5-methyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester; 3-amino-N-cyclopropyl-4-methyl-benzamide hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 45 ℃; for 1h;

With dipotassium hydrogenphosphate; In water; N,N-dimethyl-formamide; at 20 - 35 ℃;

Reference yield: 80.0%

4-chloro-5-methyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester (427878-41-9) + 3-amino-N-cyclopropyl-4-methylbenzamide (623155-19-1) → ethyl 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxylate (623152-11-4)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

ethyl 5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylate (427878-70-4) → ethyl 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxylate (623152-11-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / toluene / 36 h / 20 °C / Heating / reflux

2: N,N-dimethyl-formamide / 20 °C

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In N,N-dimethyl-formamide; toluene;

upstream raw materials:

4-chloro-5-methyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester

3-amino-N-cyclopropyl-4-methylbenzamide

3-amino-N-cyclopropyl-4-methyl-benzamide hydrochloride

ethyl 5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

Downstream raw materials:

BMS-582949

N-butyl-4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide

C₁₉H₁₈ClN₅O₂

C₂₈H₂₆N₆O₂