427878-70-4

Basic information

• Product Name: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester
• Synonyms: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester;Ethyl 5-methyl-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-6-carboxylate;5-Methyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester;Ethyl 4-hydroxy-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxylate;ethyl 4-hydroxy-5-Methyl -4a,5-dihydro pyrrolo[1,2-f][1,2,4]triazine-6-carboxylate;Ethyl 4-hydroxy-5-Methylp...;ethyl 5-Methyl-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-carboxylate;Ethyl 4-hydroxy-5-Methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate
• CAS NO: 427878-70-4
• Molecular Formula: C₁₀H₁₁N₃O₃
• Molecular Weight: 221.21264
• EINECS: -0
• Mol File: 427878-70-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 400.913 °C at 760 mmHg
• Flash Point: 196.265 °C
• Appearance: Yellow/Powder
• Density: 1.417 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.641
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester(427878-70-4)
• EPA Substance Registry System: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester(427878-70-4)

Safety Data

• Hazardous Substances Data: 427878-70-4(Hazardous Substances Data)

Usage

General Description

Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester, also known as PTCE, is a chemical compound with potential pharmacological activities. PTCE is an ethyl ester derivative of pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, which is a heterocyclic compound. Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester has been studied for its potential applications in drug development, particularly in cancer and infectious diseases. PTCE has shown inhibitory effects on certain enzymes and has demonstrated potential as an antiviral and antitumor agent. Further research is needed to fully understand the pharmacological properties and potential therapeutic applications of PTCE.

InChI:InChI=1/C10H11N3O3/c1-3-16-10(15)7-4-13-8(6(7)2)9(14)11-5-12-13/h4-5H,3H2,1-2H3,(H,11,12,14)

Upstream product

• 77287-34-4 formamide 
• 427878-69-1 1-amino-3-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 1400934-11-3 diethyl 1-(4-chlorobenzamido)-3-methyl-1H-pyrrole-2,4-dicarboxylate 
• 1400934-04-4 diethyl 1-(4-fluorobenzamido)-3-methyl-1H-pyrrole-2,4-dicarboxylate 
• 1400934-02-2 diethyl 1-(4-nitrobenzamido)-3-methyl-1H-pyrrole-2,4-dicarboxylate 
• 1400934-06-6 diethyl 1-(3-chlorobenzamido)-3-methyl-1H-pyrrole-2,4-dicarboxylate 
• 5448-16-8 3-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 134653-70-6 ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate 
• 141-97-9 ethyl acetoacetate 
• 1400934-13-5 diethyl 1-(4-methoxybenzamido)-3-methyl-1H-pyrrole-2,4-dicarboxylate 
• 1400934-08-8 diethyl 1-(4-bromobenzamido)-3-methyl-1H-pyrrole-2,4-dicarboxylate 

Downstream Products

• 623155-22-6 C₁₁H₁₀ClN₃O₃ 
• 310435-15-5 C₈H₇N₃O₃ 
• 529508-54-1 C₇H₇N₃O 
• 529508-56-3 4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine 
• 529508-57-4 5-(bromomethyl)-4-chloropyrrolo[2,1-f][1,2,4]triazine 
• 427878-02-2 N-ethyl 4-((5-(methoxycarbamoyl)-2-methylphenyl)-amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide 
• 623152-52-3 C₂₅H₂₀N₆O₃ 
• 623152-48-7 C₂₅H₂₃N₅O₂ 
• 1325229-71-7 C₂₅H₂₅N₅O₂ 
• 623155-17-9 C₂₄H₂₃N₅O₂ 
• 621685-38-9 C₂₃H₂₁N₅O₂ 
• 623155-16-8 C₂₂H₁₉N₅O₂ 
• 1401623-41-3 C₁₄H₁₃N₃O₂ 

Relevant articles and documents

TYROSINE KINASE INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present invention relates to a tyrosine kinase inhibitor and a pharmaceutical composition comprising same. The tyrosine kinase inhibitor of the present invention has the structures as shown in the following formula (I) or (II):

Development of a practical synthesis of a p38 kinase inhibitor via a safe and robust amination

The development of a practical synthesis for a p38 kinase inhibitor is described. The key advances include an improved route to the key intermediate, a substituted pyrrole, and a subsequent animation utilizing O-(4-nitrobenzoyl)- hydroxylamine, which provides a safe, scalable, and robust amination method. The new protocol was successfully demonstrated to generate 1.6 kg of API in seven steps and 26% overall yield.

Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38α mitogen-activated protein kinase inhibitors

A novel structural class of p38 mitogen-activated protein (MAP) kinase inhibitors consisting of substituted 4-(phenylamino)-pyrrolo[2,1-f][1,2,4] triazines has been discovered. An initial subdeck screen revealed that the oxindole-pyrrolo[2,1-f][1,2,4]tria