7-Bromonaphthalene-2-carbaldehyde

Base Information

• Chemical Name: 7-Bromonaphthalene-2-carbaldehyde
• CAS No.: 627527-17-7
• Molecular Formula: C11H7BrO
• Molecular Weight: 235.08
• Hs Code.: 2913000090
• DSSTox Substance ID: DTXSID60465474
• Wikidata: Q82291444
• Mol file: 627527-17-7.mol

Synonyms:7-bromonaphthalene-2-carbaldehyde;7-bromo-2-naphthaldehyde;627527-17-7;2-Naphthalenecarboxaldehyde, 7-bromo-;SCHEMBL5783154;DTXSID60465474;7-bromo-naphthalene-2-carbaldehyde;CAB52717;AKOS015962700;EN300-3088362;Z1269233153

Chemical Property of 7-Bromonaphthalene-2-carbaldehyde

Chemical Property:

• PSA: 17.07000
• LogP: 3.41480
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 233.96803
• Heavy Atom Count: 13
• Complexity: 193

Purity/Quality:

99% ^*data from raw suppliers

7-Bromo-2-naphthaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC2=C1C=CC(=C2)Br)C=O

Technology Process of 7-Bromonaphthalene-2-carbaldehyde

There total 5 articles about 7-Bromonaphthalene-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(7-bromonaphthalen-2-yl)methanol (627527-19-9) → 7-bromonaphthalene-2-carbaldehyde (627527-17-7)

Guidance literature:

With Chloro-oxo-acetic acid; triethylamine; In dichloromethane; dimethyl sulfoxide;

Reference yield: 98.0%

2,7-dibromonaphthalene (58556-75-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 7-bromonaphthalene-2-carbaldehyde (627527-17-7)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/anie.201806742

Reference yield: 50.0%

2-bromo-7-bromomethylnaphthalene (841259-75-4) → 7-bromonaphthalene-2-carbaldehyde (627527-17-7)

Guidance literature:

With 2-nitropropane; sodium ethanolate; In ethanol; at 20 ℃; for 65h;

DOI:10.1021/jm049256w

upstream raw materials:

2-bromo-7-bromomethylnaphthalene

2-bromo-7-methylnaphthalene

(7-bromonaphthalen-2-yl)methanol

2,7-dibromonaphthalene

Downstream raw materials:

4-[(7-bromo-2-naphthyl)hydroxymethyl]-3-isopropoxy-5-(1-methoxycarbonyl-4-piperidyl)isoxazol

4-[(7-bromo-2-naphthyl)methyl]-3-isopropoxy-5-(1-methoxycarbonyl-4-piperidyl)isoxazol

(7-bromonaphthalen-2-yl)methanol

(2S)-2-[4-[[(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl]oxy]phenyl]-3-(7-cyano-2-naphthyl)propionic acid ethyl ester