Ethanone, 1-[5-(1,1-dimethylethyl)-4'-methyl-6-(phenylmethoxy)[1,1'-biphenyl]-3-yl]-

Base Information

Chemical Name:Ethanone, 1-[5-(1,1-dimethylethyl)-4'-methyl-6-(phenylmethoxy)[1,1'-biphenyl]-3-yl]-
CAS No.:628337-22-4
Molecular Formula:C26H28O2
Molecular Weight:372.507
Hs Code.:

Synonyms:

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Chemical Property of Ethanone, 1-[5-(1,1-dimethylethyl)-4'-methyl-6-(phenylmethoxy)[1,1'-biphenyl]-3-yl]-

Chemical Property:

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Technology Process of Ethanone, 1-[5-(1,1-dimethylethyl)-4'-methyl-6-(phenylmethoxy)[1,1'-biphenyl]-3-yl]-

There total 7 articles about Ethanone, 1-[5-(1,1-dimethylethyl)-4'-methyl-6-(phenylmethoxy)[1,1'-biphenyl]-3-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-benzyloxy-5-tert-butyl-4'-methyl-3-biphenylcarboxylic acid

: 917-54-4
methyllithium

: 628337-22-4
1-(6-benzyloxy-5-tert-butyl-4'-methyl-3-biphenylyl) ethanone

Guidance literature:: 6-benzyloxy-5-tert-butyl-4'-methyl-3-biphenylcarboxylic acid; methyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃; for 3h;

With chloro-trimethyl-silane; In tetrahydrofuran; diethyl ether;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether;

Reference yield:

: 628337-16-6
methyl 3-tert-butyl-4-hydroxy-5-iodobenzoate

: 628337-22-4
1-(6-benzyloxy-5-tert-butyl-4'-methyl-3-biphenylyl) ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 1 h

1.2: 2 h / 20 °C

2.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 4.25 h / Heating / reflux

3.1: methanol; lithium hydroxide; water / tetrahydrofuran / 5 h / Heating / reflux

4.1: tetrahydrofuran; diethyl ether / 3 h / -78 °C

With methanol; lithium hydroxide; water; sodium hydride; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; DMF (N,N-dimethyl-formamide); diethyl ether;

Reference yield:

: 628337-15-5
3-tert-butyl-4-hydroxy-5-iodobenzoic acid

: 628337-22-4
1-(6-benzyloxy-5-tert-butyl-4'-methyl-3-biphenylyl) ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / tetrahydrofuran; water / 18 h / Heating / reflux

2.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 1 h

2.2: 2 h / 20 °C

3.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 4.25 h / Heating / reflux

4.1: methanol; lithium hydroxide; water / tetrahydrofuran / 5 h / Heating / reflux

5.1: tetrahydrofuran; diethyl ether / 3 h / -78 °C

With methanol; lithium hydroxide; water; sodium hydride; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; In tetrahydrofuran; 1,4-dioxane; DMF (N,N-dimethyl-formamide); diethyl ether; water;