628337-16-6

Upstream product

• 66737-88-0 4-hydroxy-3-tert-butyl benzoic acid 
• 39778-63-7 3-(1,1-dimethylethyl)-4-hydroxybenzoic acid methyl ester 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 67-56-1 methanol 
• 628337-15-5 3-tert-butyl-4-hydroxy-5-iodobenzoic acid 

Downstream Products

• 628337-17-7 methyl 4-benzyloxy-3-tert-butyl-5-iodobenzoate 
• 1285574-00-6 methyl 3-tert-butyl-5-iodo-4-methoxybenzoate 
• 1285573-01-4 3-(5-t-butyl-4-hydroxy-3-methylsulfonylbenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole 
• 1285572-65-7 3-(3-t-butyl-5-cyano-4-hydroxybenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole 
• 1285574-02-8 methyl 3-t-butyl-5-cyano-4-methoxybenzoate 
• 1285574-05-1 5-tert-butyl-3-cyano-4-methoxybenzoic acid 
• 1285574-07-3 3-t-butyl-5-cyano-4-methoxybenzoyl chloride 
• 1285574-08-4 3-(3-t-butyl-5-cyano-4-methoxybenzoyl)-2,3-dihydro-1,3-benzothiazole 
• 1285574-09-5 3-(3-t-butyl-5-cyano-4-methoxybenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole 
• 1285575-32-7 methyl 3-t-butyl-4-methoxy-5-methylsulfanylbenzoate 
• 1285575-33-8 methyl 3-t-butyl-4-methoxy-5-methylsulfonyl benzoate 
• 1285575-36-1 3-t-butyl-4-methoxy-5-methylsulfonyl benzoic acid 
• 1285575-37-2 3-t-butyl-4-methoxy-5-methylsulfonylbenzoyl chloride 
• 1285575-40-7 3-(3-t-butyl-4-methoxy-5-methylsulfonylbenzoyl)-2,3-dihydro-1,3-benzothiazole 

Relevant academic research and scientific papers

Novel monocyclic amide-linked phenol derivatives without mitochondrial toxicity have potent uric acid-lowering activity

Although benzbromarone (BBR) is a conventional, highly potent uricosuric drug, it is not a standard medicine because it causes rare but fatal fulminant hepatitis. We transformed the bis-aryl ketone structure of BBR to generate novel monocyclic amide-linked phenol derivatives that should possess uric acid excretion activity without adverse properties associated with BBR. The derivatives were synthesized and tested for uric acid uptake inhibition (UUI) in two assays using either urate transporter 1-expressing cells or primary human renal proximal tubule epithelial cells. We also evaluated their inhibitory activity against mitochondrial respiration as a critical mitochondrial toxicity parameter. Some derivatives with UUI activity had no mitochondrial toxicity, including compound 3f, which effectively lowered the plasma uric acid level in Cebus apella. Thus, 3f is a promising candidate for further development as a uricosuric agent.

NOVEL PHENOL DERIVATIVE

Disclosed are a novel compound and a pharmaceutical product, each having a remarkable uricosuric effect. Specifically disclosed are: a novel phenol derivative represented by general formula (1) that is shown in FIG. 1; a pharmaceutically acceptable salt t

NOVEL LIGANDS THAT ARE INHIBITORS OF THE RAR RECEPTORS, PROCESS FOR PREPARING THEM AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS

The invention relates to novel biaryl compounds corresponding to the general formula (I) below: and to the method for preparing them, and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, or alternatively in cos