Chemical Property of Dexketoprofen
Chemical Property:
- Appearance/Colour:white or almost white, crystalline powder.
- Vapor Pressure:0mmHg at 25°C
- Melting Point:75-78 °C(lit.)
- Refractive Index:1.592
- Boiling Point:431.3 °C at 760 mmHg
- PKA:4.23±0.10(Predicted)
- Flash Point:228.8 °C
- PSA：54.37000
- Density:1.198 g/cm3
- LogP:3.10570
- Storage Temp.:-20°C Freezer
- Solubility.:insoluble in H2O; ≥10.6 mg/mL in DMSO; ≥20.55 mg/mL in EtOH
- XLogP3:3.1
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:4
- Exact Mass:254.094294304
- Heavy Atom Count:19
- Complexity:331
- Purity/Quality:
-
99% *data from raw suppliers
(S)-(+)-Ketoprofen *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn, 
T
- Hazard Codes:Xn,T
- Statements:
22-36/37/38-50/53-25
- Safety Statements:
26-60-61-45
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O
- Isomeric SMILES:C[C@@H](C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O
- Recent ClinicalTrials:Dexketoprofen Dosage According to Chronotherapy
- Recent EU Clinical Trials:Comparative study between continuous perfusion and split doses in the treatment of postoperative pain
-
General Description
(S)-(+)-Ketoprofen is an enantiomerically pure form of ketoprofen, a non-steroidal anti-inflammatory drug (NSAID) used for its analgesic and anti-inflammatory properties. It can be efficiently resolved from racemic mixtures using enzymatic methods, such as hydrolysis catalyzed by engineered lipases like *Yarrowia lipolytica* Lip2p or *Candida rugosa* lipase, which exhibit improved enantioselectivity under optimized conditions. Molecular modifications of these enzymes, including site-directed mutagenesis, enhance both catalytic efficiency and stereoselectivity, enabling high-yield production of (S)-(+)-Ketoprofen. Additionally, chromatographic methods using chiral stationary phases, such as vancomycin-immobilized silica, provide effective separation of enantiomers. These biocatalytic and analytical approaches facilitate the industrial-scale preparation of optically pure (S)-(+)-Ketoprofen for pharmaceutical applications.
