1-Hydrazinyl-4-phenylphthalazine

Base Information

• Chemical Name: 1-Hydrazinyl-4-phenylphthalazine
• CAS No.: 86427-78-3
• Molecular Formula: C14H12N4
• Molecular Weight: 236.276
• Hs Code.: 2933990090
• NSC Number: 116344
• DSSTox Substance ID: DTXSID60276128
• Nikkaji Number: J405.624H
• Wikidata: Q82006485
• ChEMBL ID: CHEMBL1221468
• Mol file: 86427-78-3.mol

Synonyms:1-hydrazinyl-4-phenylphthalazine;86427-78-3;(4-Phenylphthalazin-1-yl)hydrazine;(4-Phenyl-Phthalazin-1-Yl)-Hydrazine;NSC116344;Enamine_003761;Cambridge id 5753607;Oprea1_391457;4-phenyl-1-hydrazinophthalazine;CHEMBL1221468;SCHEMBL10666164;DTXSID60276128;OZXCKWJNGZVAAJ-UHFFFAOYSA-N;HMS1404K21;BBL010059;STK801424;AKOS000122509;NSC-116344;IDI1_007404;VS-02303;1-Hydrazono-4-phenyl-1,2-dihydrophthalazine;CS-0269885;EN300-03612;AB00095829-01;SR-01000219067;SR-01000219067-1

Chemical Property of 1-Hydrazinyl-4-phenylphthalazine

Chemical Property:

• Vapor Pressure: 1.27E-11mmHg at 25°C
• Refractive Index: 1.74
• Boiling Point: 537.4 °C at 760 mmHg
• Flash Point: 278.8 °C
• PSA: 63.83000
• Density: 1.298 g/cm³
• LogP: 3.35570
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 236.106196400
• Heavy Atom Count: 18
• Complexity: 265

Purity/Quality:

99%min ^*data from raw suppliers

(4-PHENYL-PHTHALAZIN-1-YL)-HYDRAZINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NN=C(C3=CC=CC=C32)NN

Technology Process of 1-Hydrazinyl-4-phenylphthalazine

There total 4 articles about 1-Hydrazinyl-4-phenylphthalazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-chloro-4-phenyl-phthalazine (10132-01-1) → 1-hydrazinyl-4-phenylphthalazine (86427-78-3)

Guidance literature:

With hydrazine hydrate; In ethanol; for 7h; Reflux;

DOI:10.1080/14756366.2017.1279155

Reference yield:

4-phenylphthalazine-1(2H)-thione (35392-60-0) → 1-hydrazinyl-4-phenylphthalazine (86427-78-3)

Guidance literature:

With hydrazine hydrate; In toluene; for 1h; Reflux;

DOI:10.3184/030823410X12658886079090

Reference yield:

2-Benzoylbenzoic acid (85-52-9) → 1-hydrazinyl-4-phenylphthalazine (86427-78-3)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazinium sulfate; sodium hydroxide / 1 h / Reflux

2: trichlorophosphate / N,N-dimethyl-aniline / 6 h / Reflux

3: hydrazine hydrate / ethanol / 7 h / Reflux

With hydrazine hydrate; sodium hydroxide; hydrazinium sulfate; trichlorophosphate; In ethanol; N,N-dimethyl-aniline;

DOI:10.1080/14756366.2017.1279155

upstream raw materials:

1-chloro-4-phenyl-phthalazine

4-phenylphthalazine-1(2H)-thione

2-Benzoylbenzoic acid

4-phenyl-2H-phthalazin-1-one

Downstream raw materials:

3,6-Diphenyl-1,2,4-triazolo<3,4-a>phthalazine

2-(4-phenyl-1-phthalazinyl)-N-(2-propenyl)hydrazinecarbothiamide

N-[1-(2-Nitro-phenyl)-meth-(E)-ylidene]-N'-(4-phenyl-phthalazin-1-yl)-hydrazine

3-phenyl-1-(4-phenylphthalazin-1-yl)pyrazol-5-one

Refernces

• 1、 Hemdan, Magdy M.,Taha, Sherif M.,Gabr, Adel M.,Elkady, Mohamed Y.. "Hydrazine derivatives and o-benzoylbenzoic acid as a source of phthalazines with their antimicrobial activities". experimental part. p. 102 - 105. Retrieved 2010/06/19.