10132-01-1Relevant articles and documents
Phthalazine-based VEGFR-2 inhibitors: Rationale, design, synthesis, in silico, ADMET profile, docking, and anticancer evaluations
Khedr, Fathalla,Ibrahim, Mohamed-Kamal,Eissa, Ibrahim H.,Abulkhair, Hamada S.,El-Adl, Khaled
, (2021)
In the designed compounds, a new linker was inserted in the form of fragments with verified VEGFR-2 inhibitory potential, including an α,β-unsaturated ketonic fragment, pyrazole, and pyrimidine. Also, new distal hydrophobic moieties were attached to these
New 1,4-disubstituted phthalazines: Synthesis, structure and herbicidal evaluation
Bele, Constantin,Darabantu, Mircea
, p. 641 - 646 (2003)
The rapid synthesis of eighteen new 1,4-disubstituted phthalazines bearing an aryl or benzyl substituent at C-4 and a variety of aryloxy groups at C-1 is reported; full structural assignments are provided by NMR and MS data together with the biological evaluation for some representative terms of the series.
N-Substituted-4-phenylphthalazin-1-amine-derived VEGFR-2 inhibitors: Design, synthesis, molecular docking, and anticancer evaluation studies
El-Adl, Khaled,Ibrahim, Mohamed-Kamal,Khedr, Fathalla,Abulkhair, Hamada S.,Eissa, Ibrahim H.
, (2020/12/14)
In accordance with the significant impetus of the discovery of potent vascular endothelial growth factor receptor 2 (VEGFR-2) inhibitors, herein, we report the design, synthesis, and anticancer evaluation of 12 new N-substituted-4-phenylphthalazin-1-amine
A novel method for heterocyclic amide-thioamide transformations
Fathalla, Walid,Ali, Ibrahim A. I.,Pazdera, Pavel
supporting information, p. 174 - 181 (2017/02/15)
In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles. Secondly, the chloroherocycles and N-cyclohexyl dithiocarbamate cyclohexylammonium salt were heated in chloroform for 12 h at 61°C to afford heteocyclic thioamides in excellent yields.