Technology Process of Rutamarin
There total 16 articles about Rutamarin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
at 20 ℃;
for 2h;
Large scale reaction;
DOI:10.3987/COM-10-11962
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 78 percent / K2CO3, KI / acetone; H2O / Heating
2: 100 percent / H2 / Pd/BaSO4 / toluene / 760 Torr
3: 53 percent / AcONa / 1 h / 150 °C
4: 61 percent / K2CO3 / acetone / 24 h / Heating
5: 10 percent / N,N-dimethyl-acetamide / 6 h / 200 °C
6: 73 percent / m-chloroperbenzoic acid (MCPBA) / diethyl ether / 6 h
7: 92 percent / p-toluenesulfonic acid / 2 h
With
hydrogen; sodium acetate; potassium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; potassium iodide;
Pd-BaSO4;
In
diethyl ether; N,N-dimethyl acetamide; water; acetone; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 78 percent / K2CO3, KI / acetone; H2O / Heating
2: 100 percent / H2 / Pd/BaSO4 / toluene / 760 Torr
3: 53 percent / AcONa / 1 h / 150 °C
4: 61 percent / K2CO3 / acetone / 24 h / Heating
5: 10 percent / N,N-dimethyl-acetamide / 6 h / 200 °C
6: 73 percent / m-chloroperbenzoic acid (MCPBA) / diethyl ether / 6 h
7: 92 percent / p-toluenesulfonic acid / 2 h
With
hydrogen; sodium acetate; potassium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; potassium iodide;
Pd-BaSO4;
In
diethyl ether; N,N-dimethyl acetamide; water; acetone; toluene;
