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Technology Process of Oxythiamine

Oxythiamine

Base Information
  • Chemical Name:Oxythiamine
  • CAS No.:136-16-3
  • Molecular Formula:C12H16 N3 O2 S
  • Molecular Weight:266.37
  • Hs Code.:
  • UNII:1MF36SYZ22
  • DSSTox Substance ID:DTXSID40929206
  • Nikkaji Number:J5.617K
  • Wikidata:Q27147706
  • ChEMBL ID:CHEMBL3305956
  • Mol file:136-16-3.mol
Oxythiamine

Synonyms:Hydroxythiamine;Oxythiamine

Suppliers and Price of Oxythiamine
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • DC Chemicals
  • Oxythiamine(Hydroxythiamin) >98%
  • 1 g
  • $ 400.00
  • DC Chemicals
  • Oxythiamine(Hydroxythiamin) >98%
  • 100 mg
  • $ 100.00
  • CSNpharm
  • OxythiamineHCl
  • 100mg
  • $ 51.00
  • Chem-Impex
  • Oxythiamine HCl ≥ 95% (TLC)
  • 5G
  • $ 60.00
  • Chem-Impex
  • Oxythiamine HCl ≥ 95% (TLC)
  • 25G
  • $ 200.00
  • Chem-Impex
  • Oxythiamine HCl ≥ 95% (TLC)
  • 100G
  • $ 750.00
  • Biorbyt Ltd
  • Oxythiamine >98%
  • 1 g
  • $ 615.40
  • Biorbyt Ltd
  • Oxythiamine >98%
  • 250 mg
  • $ 414.80
  • Biorbyt Ltd
  • Oxythiamine >98%
  • 100 mg
  • $ 277.10
  • aablocks
  • Thiazolium,3-[(3,4-dihydro-2-methyl-4-oxo-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl- 99%
  • 500mg
  • $ 235.00
Total 10 raw suppliers
Chemical Property of Oxythiamine
Chemical Property:
  • Refractive Index:1.6740 (estimate) 
  • Boiling Point:°Cat760mmHg 
  • Flash Point:°C 
  • PSA：98.36000 
  • Density:g/cm3 
  • LogP:-1.46290 
  • Storage Temp.:−20°C 
  • XLogP3:0.1
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:4
  • Rotatable Bond Count:4
  • Exact Mass:266.09632294
  • Heavy Atom Count:18
  • Complexity:395
Purity/Quality:

97% *data from raw suppliers

Oxythiamine(Hydroxythiamin) >98% *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC1=C(SC=[N+]1CC2=CN=C(NC2=O)C)CCO
Refernces

Differences in the efficiency of 3-deazathiamine and oxythiamine pyrophosphates as inhibitors of pyruvate dehydrogenase complex and growth of HeLa cells in?vitro

10.1080/14756366.2020.1844681

The research investigates the inhibitory effects of oxythiamine pyrophosphate (OTPP) and 3-deazathiamine pyrophosphate (DATPP) on the pyruvate dehydrogenase complex (PDHC) and their impact on HeLa cell growth. The study found that DATPP was a stronger competitive inhibitor of PDHC with a Ki value of 0.0026 mM compared to OTPP's Ki value of 0.025 mM. However, despite its superior inhibitory properties on PDHC, DATPP did not significantly affect HeLa cell growth or viability, whereas OTPP and oxythiamine (OT) showed a significant cytostatic effect. The researchers hypothesize that the differences in the cytostatic effects may be due to the physicochemical properties of the compounds and the difficulty in transporting DATPP across the cell membrane. The findings suggest that while DATPP is a potent inhibitor of PDHC, its effectiveness as a cytostatic agent may be limited by its cellular uptake and transport mechanisms.

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