Arginylarginine 2-naphthylamide

Base Information

• Chemical Name: Arginylarginine 2-naphthylamide
• CAS No.: 15483-59-7
• Molecular Formula: C22H33 N9 O2
• Molecular Weight: 455.563
• DSSTox Substance ID: DTXSID20165746
• Nikkaji Number: J1.715.967D
• ChEMBL ID: CHEMBL1222048
• Mol file: 15483-59-7.mol

Synonyms:Arg-Arg-2-NNap;arginylarginine 2-naphthylamide

Chemical Property of Arginylarginine 2-naphthylamide

Chemical Property:

• Boiling Point: °Cat760mmHg
• PKA: 13.86±0.46(Predicted)
• Flash Point: °C
• PSA: 215.00000
• Density: 1.39g/cm³
• LogP: 4.68890
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 12
• Exact Mass: 455.27572133
• Heavy Atom Count: 33
• Complexity: 689

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C=C(C=CC2=C1)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)N
• Isomeric SMILES: C1=CC=C2C=C(C=CC2=C1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)N

Technology Process of Arginylarginine 2-naphthylamide

There total 1 articles about Arginylarginine 2-naphthylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

CBzl-Arg-Arg-β-naphtylamide (76474-52-7) → arginyl-arginine-2-naphthyl-amide (15483-59-7)

Guidance literature:

With TES buffer; Adenohypophyseal enzyme; at 35 ℃; Rate constant; Optimum pH for hydrolysis;

Reference yield:

Arg2-2-naphthylamine (15483-59-7) → naphthalen-2-ylamine (91-59-8)

Guidance literature:

With human dipeptidyl peptidase III, a metallopeptidase of the M₄₉ family; In aq. buffer; at 26 ℃; pH=8; Reagent/catalyst; Kinetics; Enzymatic reaction;

DOI:10.1515/hsz-2012-0347

Reference yield:

Arg2-2-naphthylamine (15483-59-7) → Nα-L-arginyl-L-arginine (15483-27-9,455-64-1) + naphthalen-2-ylamine (91-59-8)

Guidance literature:

With water; at 37 ℃; for 1h; buffer: Tris (pH: 8.0); dipeptidyl aminopeptidase III (Saccharomyces cerevisiae);

DOI:10.1248/cpb.38.246

upstream raw materials:

CBzl-Arg-Arg-β-naphtylamide

Downstream raw materials:

N^α-L-arginyl-L-arginine

naphthalen-2-ylamine