1-Propanone, 2-chloro-2-fluoro-1-phenyl- (9CI)

Base Information

• Chemical Name: 1-Propanone, 2-chloro-2-fluoro-1-phenyl- (9CI)
• CAS No.: 63017-20-9
• Molecular Formula: C9H8ClFO
• Molecular Weight: 186.61100
• Mol file: 63017-20-9.mol

Synonyms:1-PROPANONE,2-CHLORO-2-FLUORO-1-PHENYL;2-chloro-2-fluoropropiophenone;2-Chlor-2-Fluor-1-Phenyl-1-Propanon;1-Phenyl-2-Fluor-2-Chlor-1-Propanon;

Chemical Property of 1-Propanone, 2-chloro-2-fluoro-1-phenyl- (9CI)

Chemical Property:

• PSA: 17.07000
• LogP: 2.79380

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Propanone, 2-chloro-2-fluoro-1-phenyl- (9CI)

There total 4 articles about 1-Propanone, 2-chloro-2-fluoro-1-phenyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-fluoroethyl phenyl ketone (21120-36-5,88208-12-2) → 2-chloro-2-fluoro-1-phenylpropane-1-one (63017-20-9)

Guidance literature:

With chlorine; In N,N-dimethyl-formamide; at 100 ℃; for 0.5h;

DOI:10.1021/jo01302a011

Reference yield:

2-bromo-2-chloropropiophenone (63017-05-0) → 2-chloro-2-fluoro-1-phenylpropane-1-one (63017-20-9)

Guidance literature:

With mercury(II) fluoride; at 140 - 160 ℃;

DOI:10.1021/jo00442a017

Reference yield:

2-bromo-1-phenyl-1-propanone (2114-00-3) → 2-chloro-2-fluoro-1-phenylpropane-1-one (63017-20-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / KF / dimethylformamide / 3 h / 110 °C

2: 82 percent / Cl₂ / dimethylformamide / 0.5 h / 100 °C

With potassium fluoride; chlorine; In N,N-dimethyl-formamide;

DOI:10.1021/jo01302a011

upstream raw materials:

2-bromo-2-chloropropiophenone

1-fluoroethyl phenyl ketone

2-bromo-1-phenyl-1-propanone

2-chloro-1-phenylpropan-1-one

Downstream raw materials:

1,1-dimethoxy-1-phenylpropan-2-one

1-methoxy-1-phenyl-acetone