Ethyl 1,4-bis(3,4,5-trimethoxybenzoyl)-2-piperazinecarboxylate

Base Information

Chemical Name:Ethyl 1,4-bis(3,4,5-trimethoxybenzoyl)-2-piperazinecarboxylate
CAS No.:129477-58-3
Molecular Formula:C27H34 N2 O10
Molecular Weight:546.5663
Hs Code.:
DSSTox Substance ID:DTXSID80926416

Synonyms:Ethyl 1,4-bis(3,4,5-trimethoxybenzoyl)-2-piperazinecarboxylate;129477-58-3;N,N'-Di-(3',4',5'-trimethoxybenzoyl)-2-ethoxycarbonylpiperazine;2-Piperazinecarboxylic acid, 1,4-bis(3,4,5-trimethoxybenzoyl)-, ethyl ester;ethyl 1,4-bis(3,4,5-trimethoxybenzoyl)piperazine-2-carboxylate;SCHEMBL10459458;DTXSID80926416;LS-110830

Suppliers and Price of Ethyl 1,4-bis(3,4,5-trimethoxybenzoyl)-2-piperazinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Ethyl 1,4-bis(3,4,5-trimethoxybenzoyl)-2-piperazinecarboxylate

Chemical Property:

Vapor Pressure:1.67E-20mmHg at 25°C
Boiling Point:718.7°Cat760mmHg
Flash Point:388.4°C
Density:1.24g/cm³
XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:11
Exact Mass:546.22134529
Heavy Atom Count:39
Complexity:800

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1CN(CCN1C(=O)C2=CC(=C(C(=C2)OC)OC)OC)C(=O)C3=CC(=C(C(=C3)OC)OC)OC

Technology Process of Ethyl 1,4-bis(3,4,5-trimethoxybenzoyl)-2-piperazinecarboxylate

There total 3 articles about Ethyl 1,4-bis(3,4,5-trimethoxybenzoyl)-2-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.6%

: 4521-61-3
3,4,5-Trimethoxybenzoyl chloride

: 129798-91-0
ethyl piperazine-2-carboxylate dihydrochloride

: 129477-58-3
2-ethyloxycarbonyl-1,4-bis(3,4,5-trimethoxybenzoyl)piperazine

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm040860g

Reference yield:

: ethyl 1,4-bis(phenylmethyl)-2-piperazine carboxylate dihydrochloride

: 129477-58-3
2-ethyloxycarbonyl-1,4-bis(3,4,5-trimethoxybenzoyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / H₂; aq. HCl / Pd/C / 40 °C

2: 39.6 percent / Et₃N / CH₂Cl₂ / 20 °C

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In dichloromethane;
DOI:10.1021/jm040860g