5-(3-Methoxybenzyl)-2-methylthio-4-pyrimidone

Base Information

Chemical Name:5-(3-Methoxybenzyl)-2-methylthio-4-pyrimidone
CAS No.:63204-40-0
Molecular Formula:C13H14N2O2S
Molecular Weight:262.332
Hs Code.:
DSSTox Substance ID:DTXSID901180737

Synonyms:5-(3-methoxybenzyl)-2-methylthio-4-pyrimidone;SCHEMBL10739261;IHSROGNPBGFSLC-UHFFFAOYSA-N;DTXSID901180737;63204-40-0;5-[(3-Methoxyphenyl)methyl]-2-(methylthio)-4(3H)-pyrimidinone

Suppliers and Price of 5-(3-Methoxybenzyl)-2-methylthio-4-pyrimidone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(3-Methoxybenzyl)-2-methylthio-4-pyrimidone

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:262.07759887
Heavy Atom Count:18
Complexity:379

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC(=C1)CC2=CN=C(NC2=O)SC

Technology Process of 5-(3-Methoxybenzyl)-2-methylthio-4-pyrimidone

There total 6 articles about 5-(3-Methoxybenzyl)-2-methylthio-4-pyrimidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 28495-90-1
5-(3-methoxy-benzyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

: 74-88-4
methyl iodide

: 63204-40-0
5-(3-methoxy-benzyl)-2-methylsulfanyl-1H-pyrimidin-4-one

Guidance literature:: With sodium hydroxide; In ethanol; at 60 ℃;
DOI:10.1016/0223-5234(88)90167-5

Reference yield:

: 33877-04-2,24393-55-3
ethyl (E)-3-(3-methoxyphenyl)acrylate

: 63204-40-0
5-(3-methoxy-benzyl)-2-methylsulfanyl-1H-pyrimidin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / 5percent Pd/C / ethanol

2: sodium wire / diethyl ether / 18 h / Ambient temperature

3: ethanol / 7 h / Heating

4: 90 percent / aq. NaOH / ethanol / 60 °C

With sodium hydroxide; hydrogen; sodium; palladium on activated charcoal; In diethyl ether; ethanol;
DOI:10.1016/0223-5234(88)90167-5

Reference yield:

: 591-31-1
3-methoxy-benzaldehyde

: 63204-40-0
5-(3-methoxy-benzyl)-2-methylsulfanyl-1H-pyrimidin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1) piperidine, 2) conc. H₂SO₄ / 1) pyridine

2: hydrogen / 5percent Pd/C / ethanol

3: sodium wire / diethyl ether / 18 h / Ambient temperature

4: ethanol / 7 h / Heating

5: 90 percent / aq. NaOH / ethanol / 60 °C

With piperidine; sodium hydroxide; sulfuric acid; hydrogen; sodium; palladium on activated charcoal; In diethyl ether; ethanol;
DOI:10.1016/0223-5234(88)90167-5