Technology Process of Silane,
(1,1-dimethylethyl)dimethyl[[(2S,3R,5S,6R)-tetrahydro-6-methyl-5-(phen
ylmethoxy)-6-[2-(phenylmethoxy)ethyl]-2-(2-propynyl)-2H-pyran-3-yl]oxy]-
There total 10 articles about Silane,
(1,1-dimethylethyl)dimethyl[[(2S,3R,5S,6R)-tetrahydro-6-methyl-5-(phen
ylmethoxy)-6-[2-(phenylmethoxy)ethyl]-2-(2-propynyl)-2H-pyran-3-yl]oxy]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
methanol;
at 20 ℃;
for 19h;
DOI:10.1021/jo035145d
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 100 percent / KHMDS / tetrahydrofuran; toluene / 0.5 h / 0 °C
2: 100 percent / TBAF / tetrahydrofuran / 18 h / 20 °C
3: 2,6-lutidine / CH2Cl2 / 0.5 h / -78 °C
4: 1.84 g / 2,6-lutidine / CH2Cl2 / 0.75 h
5: 95 percent / n-BuLi / hexane; tetrahydrofuran / 0.75 h / -78 °C
6: 96 percent / K2CO3 / methanol / 19 h / 20 °C
With
2,6-dimethylpyridine; n-butyllithium; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; potassium carbonate;
In
tetrahydrofuran; methanol; hexane; dichloromethane; toluene;
DOI:10.1021/jo035145d
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 81 percent / n-BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran; hexane / 0.5 h / -100 °C
2: 93 percent / TsOH*H2O / CH2Cl2 / 23 h / 0 °C
3: 99 percent / NaBH4 / methanol; CH2Cl2 / 1 h / -78 °C
4: 100 percent / KHMDS / tetrahydrofuran; toluene / 0.5 h / 0 °C
5: 100 percent / TBAF / tetrahydrofuran / 18 h / 20 °C
6: 2,6-lutidine / CH2Cl2 / 0.5 h / -78 °C
7: 1.84 g / 2,6-lutidine / CH2Cl2 / 0.75 h
8: 95 percent / n-BuLi / hexane; tetrahydrofuran / 0.75 h / -78 °C
9: 96 percent / K2CO3 / methanol / 19 h / 20 °C
With
2,6-dimethylpyridine; sodium tetrahydroborate; n-butyllithium; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; potassium carbonate; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; toluene;
DOI:10.1021/jo035145d
