Benzeneethanol, beta-((4-(2-(dimethylamino)ethoxy)phenyl)(4-hydroxyphenyl)methylene)-alpha-methyl-, (betaE)-

Base Information

Chemical Name:Benzeneethanol, beta-((4-(2-(dimethylamino)ethoxy)phenyl)(4-hydroxyphenyl)methylene)-alpha-methyl-, (betaE)-
CAS No.:194279-77-1
Molecular Formula:C₂₆H₂₉NO₃
Molecular Weight:403.521
Hs Code.:
Nikkaji Number:J952.863F

Synonyms:alpha,4-dihydroxytamoxifen

Suppliers and Price of Benzeneethanol, beta-((4-(2-(dimethylamino)ethoxy)phenyl)(4-hydroxyphenyl)methylene)-alpha-methyl-, (betaE)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Benzeneethanol, beta-((4-(2-(dimethylamino)ethoxy)phenyl)(4-hydroxyphenyl)methylene)-alpha-methyl-, (betaE)-

Chemical Property:

Vapor Pressure:1.08E-13mmHg at 25°C
Boiling Point:567°Cat760mmHg
Flash Point:296.7°C
Density:1.144g/cm³
XLogP3:5.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:403.21474379
Heavy Atom Count:30
Complexity:524

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3)O
Isomeric SMILES:CC(/C(=C(\C1=CC=C(C=C1)O)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3)O

Technology Process of Benzeneethanol, beta-((4-(2-(dimethylamino)ethoxy)phenyl)(4-hydroxyphenyl)methylene)-alpha-methyl-, (betaE)-

There total 5 articles about Benzeneethanol, beta-((4-(2-(dimethylamino)ethoxy)phenyl)(4-hydroxyphenyl)methylene)-alpha-methyl-, (betaE)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 556834-80-1
(E,Z)-4-[4-(2-dimethylaminoethoxy)phenyl]-4-(4-hydroxyphenyl)-3-phenyl-but-3-en-2-one

: 194279-77-1
(E)-4-{1-[4-(2-dimethylaminoethoxy)phenyl]-3-hydroxy-2-phenyl-but-1-enyl}phenol

Guidance literature:: With sodium tetrahydroborate; cerium(III) chloride; In methanol; at 20 ℃; for 3h;
DOI:10.1080/00304940309355839

Reference yield:

: 140-29-4
phenylacetonitrile

: 194279-77-1
(E)-4-{1-[4-(2-dimethylaminoethoxy)phenyl]-3-hydroxy-2-phenyl-but-1-enyl}phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / diethyl ether / 2.5 h / Heating

1.2: tetrahydrofuran; diethyl ether / Heating

1.3: 97 percent / 2N HCl / methanol; tetrahydrofuran / 1.5 h / 20 °C

2.1: diethyl ether; tetrahydrofuran / -78 - 20 °C

3.1: 4.45 g / 2N HCl / tetrahydrofuran / 14 h / 70 °C

4.1: CeCl₃; NaBH₄ / methanol / 3 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; cerium(III) chloride; sodium hydride; In tetrahydrofuran; methanol; diethyl ether; 4.1: Luche reduction;
DOI:10.1080/00304940309355839

Reference yield:

: 503273-10-7
[4-(2-dimethylaminoethoxy)phenyl]-(4-methoxymethoxyphenyl)methanone

: 194279-77-1
(E)-4-{1-[4-(2-dimethylaminoethoxy)phenyl]-3-hydroxy-2-phenyl-but-1-enyl}phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / diethyl ether / 2.5 h / Heating

1.2: tetrahydrofuran; diethyl ether / Heating

1.3: 97 percent / 2N HCl / methanol; tetrahydrofuran / 1.5 h / 20 °C

2.1: diethyl ether; tetrahydrofuran / -78 - 20 °C

3.1: 4.45 g / 2N HCl / tetrahydrofuran / 14 h / 70 °C

4.1: CeCl₃; NaBH₄ / methanol / 3 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; cerium(III) chloride; sodium hydride; In tetrahydrofuran; methanol; diethyl ether; 4.1: Luche reduction;
DOI:10.1080/00304940309355839