(E,Z)-3-[4-(2-dimethylaminoethoxy)phenyl]-3-(4-methoxymethoxyphenyl)-2-phenylacrylonitrile

Base Information

Chemical Name:(E,Z)-3-[4-(2-dimethylaminoethoxy)phenyl]-3-(4-methoxymethoxyphenyl)-2-phenylacrylonitrile
CAS No.:556834-79-8
Molecular Formula:C₂₇H₂₈N₂O₃
Molecular Weight:428.531
Hs Code.:

Synonyms:(E,Z)-3-[4-(2-dimethylaminoethoxy)phenyl]-3-(4-methoxymethoxyphenyl)-2-phenylacrylonitrile

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Chemical Property of (E,Z)-3-[4-(2-dimethylaminoethoxy)phenyl]-3-(4-methoxymethoxyphenyl)-2-phenylacrylonitrile

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Technology Process of (E,Z)-3-[4-(2-dimethylaminoethoxy)phenyl]-3-(4-methoxymethoxyphenyl)-2-phenylacrylonitrile

There total 1 articles about (E,Z)-3-[4-(2-dimethylaminoethoxy)phenyl]-3-(4-methoxymethoxyphenyl)-2-phenylacrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 140-29-4
phenylacetonitrile

: 503273-10-7
[4-(2-dimethylaminoethoxy)phenyl]-(4-methoxymethoxyphenyl)methanone

: 556834-79-8
(E,Z)-3-[4-(2-dimethylaminoethoxy)phenyl]-3-(4-methoxymethoxyphenyl)-2-phenylacrylonitrile

Guidance literature:: phenylacetonitrile; With sodium hydride; In diethyl ether; for 2.5h; Heating;

[4-(2-dimethylaminoethoxy)phenyl]-(4-methoxymethoxyphenyl)methanone; In tetrahydrofuran; diethyl ether; Heating;

With hydrogenchloride; In tetrahydrofuran; methanol; at 20 ℃; for 1.5h;
DOI:10.1080/00304940309355839

Reference yield:

: 556834-79-8
(E,Z)-3-[4-(2-dimethylaminoethoxy)phenyl]-3-(4-methoxymethoxyphenyl)-2-phenylacrylonitrile

: 194279-77-1
(E)-4-{1-[4-(2-dimethylaminoethoxy)phenyl]-3-hydroxy-2-phenyl-but-1-enyl}phenol

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether; tetrahydrofuran / -78 - 20 °C

2: 4.45 g / 2N HCl / tetrahydrofuran / 14 h / 70 °C

3: CeCl₃; NaBH₄ / methanol / 3 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; cerium(III) chloride; In tetrahydrofuran; methanol; diethyl ether; 3: Luche reduction;
DOI:10.1080/00304940309355839

Reference yield:

: 556834-79-8
(E,Z)-3-[4-(2-dimethylaminoethoxy)phenyl]-3-(4-methoxymethoxyphenyl)-2-phenylacrylonitrile

: 556834-80-1
(E,Z)-4-[4-(2-dimethylaminoethoxy)phenyl]-4-(4-hydroxyphenyl)-3-phenyl-but-3-en-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether; tetrahydrofuran / -78 - 20 °C

2: 4.45 g / 2N HCl / tetrahydrofuran / 14 h / 70 °C

With hydrogenchloride; In tetrahydrofuran; diethyl ether;
DOI:10.1080/00304940309355839