3-(4-BOC-piperazino)-2-chloropyridine

Base Information

• Chemical Name: 3-(4-BOC-piperazino)-2-chloropyridine
• CAS No.: 633283-64-4
• Molecular Formula: C14H20ClN3O2
• Molecular Weight: 297.785
• Mol file: 633283-64-4.mol

Synonyms:tert-butyl 4-(2-chloropyridin-3-yl)piperazine-1-carboxylate;t-butyl 4-(2-chloro-3-pyridyl)piperazine-1-carboxylate;4-(2-chloro-pyridin-3-yl)-piperazine-1-carboxylic acid t-butyl ester;

Chemical Property of 3-(4-BOC-piperazino)-2-chloropyridine

Chemical Property:

• PSA: 45.67000
• LogP: 2.79500

Purity/Quality:

3-(4-BOC-piperazino)-2-chloropyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-BOC-piperazino)-2-chloropyridine

There total 2 articles about 3-(4-BOC-piperazino)-2-chloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-chloro-3-iodopyridine (78607-36-0) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 1-N-(tert-butoxycarbonyl)-4-N-(2-chloropyridin-3-yl)piperazine (633283-64-4)

Guidance literature:

With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 100 ℃; for 3.5h;

Reference yield: 87.0%

3-bromo-2-chloropyridine (52200-48-3) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 1-N-(tert-butoxycarbonyl)-4-N-(2-chloropyridin-3-yl)piperazine (633283-64-4)

Guidance literature:

With 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene; at 100 ℃; for 3h;

DOI:10.1021/ol0357696

Reference yield: 84.0%

(4-isopropylphenyl)boronic acid (16152-51-5) + 1-N-(tert-butoxycarbonyl)-4-N-(2-chloropyridin-3-yl)piperazine (633283-64-4) → C23H31N3O2 (1377551-45-5)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 1h;

DOI:10.1021/jm300403a

upstream raw materials:

3-bromo-2-chloropyridine

1-t-Butoxycarbonylpiperazine

2-chloro-3-iodopyridine

Downstream raw materials:

C₂₃H₃₁N₃O₂

(R)-1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol

(S)-1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol

1-(4-methoxyphenoxy)-3-[4-[2-(3-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol

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