(R)-1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol

Base Information

Chemical Name:(R)-1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol
CAS No.:1607802-86-7
Molecular Formula:C₂₄H₂₈N₄O₃
Molecular Weight:420.511
Hs Code.:

Synonyms:(R)-1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol

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Chemical Property of (R)-1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol

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Technology Process of (R)-1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol

There total 5 articles about (R)-1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1567833-54-8
1-[2-(4-pyridyl)-3-pyridyl]piperazine

: 2211-94-1,51469-79-5,71048-65-2,71031-04-4,26744-15-0
4-methoxybenzyloxy ester of (S)-glycidol

: 1607802-86-7
(R)-1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol

Guidance literature:: In ethanol; Reflux;
DOI:10.1016/j.ejmech.2014.03.066

Reference yield:

: 633283-64-4
1-N-(tert-butoxycarbonyl)-4-N-(2-chloropyridin-3-yl)piperazine

: 1607802-86-7
(R)-1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 22 h / 100 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3: ethanol / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; trifluoroacetic acid; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.03.066

Reference yield:

: 1692-15-5
4-pyridylboronic acid

: 1607802-86-7
(R)-1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 22 h / 100 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3: ethanol / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; trifluoroacetic acid; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.03.066