2H-Pyran-4-ol, 2-[2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-oxazolyl]tetrahydro-6 -[2-[(4-methoxyphenyl)methoxy]ethyl]-, (2R,4S,6R)-

Base Information

Chemical Name:2H-Pyran-4-ol, 2-[2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-oxazolyl]tetrahydro-6 -[2-[(4-methoxyphenyl)methoxy]ethyl]-, (2R,4S,6R)-
CAS No.:633305-53-0
Molecular Formula:C25H39NO6Si
Molecular Weight:477.673
Hs Code.:

2H-Pyran-4-ol,
2-[2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-oxazolyl]tetrahydro-6
-[2-[(4-methoxyphenyl)methoxy]ethyl]-, (2R,4S,6R)-

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Chemical Property of 2H-Pyran-4-ol, 2-[2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-oxazolyl]tetrahydro-6 -[2-[(4-methoxyphenyl)methoxy]ethyl]-, (2R,4S,6R)-

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Technology Process of 2H-Pyran-4-ol, 2-[2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-oxazolyl]tetrahydro-6 -[2-[(4-methoxyphenyl)methoxy]ethyl]-, (2R,4S,6R)-

There total 5 articles about 2H-Pyran-4-ol, 2-[2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-oxazolyl]tetrahydro-6 -[2-[(4-methoxyphenyl)methoxy]ethyl]-, (2R,4S,6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 633305-52-9
6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-2-[2-(4-methoxy-benzyloxy)-ethyl]-3,4-dihydro-2H-pyran-4-ol

: 633305-53-0
(2R,4S,6R)-2-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-6-[2-(4-methoxy-benzyloxy)-ethyl]-tetrahydro-pyran-4-ol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 8h;
DOI:10.1055/s-2003-41462

Reference yield: 65.0%

: 633305-51-8
6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-2-[2-(4-methoxy-benzyloxy)-ethyl]-2,3-dihydro-pyran-4-one

: 633305-53-0
(2R,4S,6R)-2-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-6-[2-(4-methoxy-benzyloxy)-ethyl]-tetrahydro-pyran-4-ol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 8h; pH=1;
DOI:10.1055/s-2003-41462

Reference yield:

: 633305-50-7
(R)-6-(2-Hydroxymethyl-oxazol-4-yl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-2,3-dihydro-pyran-4-one

: 633305-53-0
(2R,4S,6R)-2-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-6-[2-(4-methoxy-benzyloxy)-ethyl]-tetrahydro-pyran-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / imidazole / dimethylformamide / 5 h / 20 °C

2: 95 percent / CeCl₃*7H₂O; NaBH₄ / methanol / 0.33 h / -78 °C

3: 95 percent / H₂ / Pd/C / ethyl acetate / 8 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; cerium(III) chloride; hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; N,N-dimethyl-formamide; 2: Luche reduction;
DOI:10.1002/chem.200500892