1-(2-Aminoanilino)propan-2-ol

Base Information

• Chemical Name: 1-(2-Aminoanilino)propan-2-ol
• CAS No.: 63346-84-9
• Molecular Formula: C₉H₁₄N₂O
• Molecular Weight: 166.223
• DSSTox Substance ID: DTXSID00601556
• Mol file: 63346-84-9.mol

Synonyms:1-(2-Aminoanilino)propan-2-ol;63346-84-9;SCHEMBL8046096;DTXSID00601556;AKOS000283184;AKOS022478709;1-[(2-AMINOPHENYL)AMINO]PROPAN-2-OL;F1911-3663

Chemical Property of 1-(2-Aminoanilino)propan-2-ol

Chemical Property:

• XLogP3: 0.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 166.110613074
• Heavy Atom Count: 12
• Complexity: 130

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CNC1=CC=CC=C1N)O

Technology Process of 1-(2-Aminoanilino)propan-2-ol

There total 4 articles about 1-(2-Aminoanilino)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.4%

→ C10H14N2O3 + 1-(2-amino-anilino)-propan-2-ol (63346-84-9) + 1,3-bis-(2-aminophenyl)urea (150399-28-3)

Guidance literature:

With sodium iodide; 1-(n-butyl)-3-methylimidazolium tetrachloroindate; In tetrahydrofuran; at 150 ℃; for 2h; under 62819.5 Torr;

Reference yield:

1-(2-nitro-anilino)-propan-2-ol (57610-03-4) → 1-(2-amino-anilino)-propan-2-ol (63346-84-9)

Guidance literature:

With potassium hydroxide; sodium dithionite;

DOI:10.1021/ja01875a002

Reference yield:

2-Chloronitrobenzene (88-73-3) → 1-(2-amino-anilino)-propan-2-ol (63346-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate

2: aqueous hydrochloric acid; tin

With hydrogenchloride; tin; sodium carbonate;

DOI:10.1021/ja01875a002

upstream raw materials:

1-(2-nitro-anilino)-propan-2-ol

1,2-diamino-benzene

methyloxirane

2-Chloronitrobenzene